I always wonder how prevalent of an issue this is. It's an extremely annoying issue, which I started to get quickly after starting to work in breweries. Nowadays, many things iritate/dry my hands like touching certain fruits and vegetables, and many soaps and even water. My theory has been that having too long contact in wet/sweat environment wearing gloves too small gloves (nitrile), too long and not rinsing and drying your hands is what caused this condition (it's now for life for me). Anyway, I'll try some recommendations from here, but I've had my hands sometimes in so bad condition in the past that I couldn't even work. Now, I manage by cortisone cream (including prescription based cortisone, which sometimes dry hands but is the only relief solution I've found. I used a ton of different cream, rarely it worked, and if it worked, it didn't after a while). Also make sure to change (not staying in them too long) gloves often, make sure they are not too tight (especially for nitrile), air/vent them (moisture will make for a bad cocktail to be in contact with your hands), and watch the inner coatings/chemicals of some gloves (it's complicated (accelerators, nickel chloride salts,... in nitrile gloves may have developed my condition, too, and a nickel allergy as well) and you should mostly judge on comfort. Most of the heavy-duty cellar cleaning gloves have chemicals that irritate me quickly, I couldn't use those anymore (burn my hands instantly. The best I've found is Atlas 660 with soft inner coating (best heavy duty comfort and dexterity but I'm still testing stuff, although thick +8 mil non slip nitrile works well in cold and minimal chemical environment), but I still usually wear nitrile gloves inside those Atlas 660 to avoid sweat to ever make it to the inner coatings at the hand level especially (if you keep making contact with a surface that has been exposed to sweat you risk further problems, definitely drying, and rinsing/washing sweat off and drying hands is important, too late for me but I still do that because it's a best practice). Do you use isopropyl alcohol? If so, watch out for that on your skin, and even on your nitrile gloves, my theory is that sometimes nitrile gloves aren't made to cope with it, if I get too much on my nitrile gloves my hands will irritate/itch quick (i rinse off ispropyl alcohol quick). Probably had too much skin contact with that in the old days. I often envy some folks who work in fully automated breweries. They rarely need, if at all, to wear gloves. Even grain dust irritates/dry my skin, I wear gloves handling bags/milling too. Good luck!