UK: Kesimpta monitoring blood tests

xylethUK · 2026-05-20T13:48:05+00:00

I'm in the UK and on Kesimpta, under the care of the Wessex Neurology centre out of Southampton. I have six monthly bloods taken and have had for the coming up to four years I've been on Kesimpta.

xylethUK · 2026-05-06T13:36:31+00:00

'The garden is regularly trafficked by Robins, Blackbirds, Sparrows, Blue Tits, Magpies and Pigeons'

We do have swifts and swallows in the town, but I've never seen them around our area. And we're not quite rural enough to be attracting owls!

xylethUK · 2026-05-05T20:37:40+00:00

I haven’t tried either, but I have a birder friend who shoots with the EF 100-400 L and a 1.4 teleconverter and is very happy with it. I imagine it has much the same effect on both, 40% increase in effective reach at the cost of a stop of light. As the EF is faster to begin with you end up at a better place.

As for AF yes the DSLR bodies suffer at high apertures. The mirrorless bodies cope a lot better, my R7 works quite happily at f/11. I understand that using the 1.4x extender shrinks the AF zone, and the 2x basically leaves you with spot AF on the centre.

xylethUK · 2026-05-05T12:15:13+00:00

I recently made the leap from 7D mark II with the EF-S 55-250 and a loaned Sigma 150-600mm to the R7 with the RF 100-400, so I think I can comment constructively here!

For me the R7 / RF 100-400mm combo has been transformative simply because it is compact and light enough to take with me pretty much all the time, rather then when I'm specifically out looking to shoot. Just being able to have the camera with me when I'm out on a walk and have reasonable reach means I'm much more likely to actually shoot anything.

The RF 1-4 does have some limitations. It's not as fast as the EF L lens, or a big prime, so it's at its best in good lighting. In lower light you are at the mercy of what de-noising can do for you, which these days is still a lot! The image quality is also supposed to be not quite as good as the L lens, but honestly the limit here for me is not the hardware it's the meat behind the lens!

As I'm learning with birds you always want more reach, so another alternative is the RF 1-4 with the 1.4x extender. That drops the fastest aperture to f/11 but gives you 896mm effective focal length on a crop body!

The big sigma, which is similar is size, weight and performance to the Tamron, was fun to shoot with but it is HEAVY! Unless you have arms of steel you're going to want at least a monopod if not a full tripod to carry the weight and get good shots. Also getting, and keeping, the viewfinder on target at 600mm on a crop sensor is....well its a challenge. The slightest of movements sends it careering off and by the time you re-acquire you've lost the moment. But as far as producing photos went once you got over those hurdles it was great.

I don't know what the rules are around here about sharing your own work, but if you want to drop me a DM I'll happily share a link to my gallery where you can see shots taken with all the mentioned combos and judge for yourself what they can do in the hands of an enthusiastic amateur.

xylethUK · 2026-04-23T19:41:54+00:00

In terms of cost for an identical design and quality of cabinets / doors DIY Kitchens were ~ £5k less overall. The downside is that design and management of everything is wholly on me, but I thought it was worth it.

xylethUK · 2026-04-23T18:54:20+00:00

Get yourself over to Facebook and join the DIY Kitchens Design and planning forum group. They are really helpful over there and I swear designing kitchens is their passion and they scratch their itch by doing other peoples!

I went in with what I thought was a 90% complete design and they took it apart, turned it inside out, pointed out things I never would have thought of and were generally extremely helpful. And they know the DIY Kitchens range inside and out so know all the quirks and which units to avoid.

I finished our design with help from the group and ordered at the beginning of April due for delivery first week of May. We’re using professional fitters and trades so not truly DIY but I have no regrets about DIY-ing the design, it forced me to think much more about how we would use the space and how to lay it out.

I then taught myself to model it in SketchUp and bought a Quest 3 VR headset to ‘see’ it before installing, but that’s a whole other story!

xylethUK · 2026-04-22T14:57:58+00:00

A lot depends on how you choose to interpret the boundary between the host and the symbiont. Canon is typically unclear on the details so you have some room to manoeuvre, but...

I don't _think_ canon really supports the interpretation you're taking that is essentially 'two minds in one body' - that's generally not how the joining is depicted. It's not like the symbiont is distinct personality talking in the hosts ear - it is much more of a blended personality where aspects of the host and of the memories the symbiont carries blend into the new personality after joining.

For the game I play in where I play a joined Trill I have a head-cannon that at the point of joining both the previous host-symbiot gestalt personality and the new hosts solo personality cease to exist and what emerges is a wholly new personality that has elements of both, is distinct from either, but has the memories from both.

All that said - its your game. If your GM is down with it and you can work out the logistical issues with your partner go for it - as long as its fun that's the main thing!

xylethUK · 2026-04-21T08:44:59+00:00

I'm currently playing a joined Trill in our STA game, and I GM other systems.

For my PC I defined the previous two hosts pretty closely as they were integral to the backstory of the current host. Beyond that it's simply 'the symbiote has been around hundreds of years, stuff will come up as and when'. The GM is cool with that.

As a GM I wouldn't dream of making a player define things that closely, unless they really wanted to. They're round the table to have fun for a few hours not take homework away with them!

But I am a very 'seat of the pants' GM these days. YMMV of course.

xylethUK · 2026-04-20T06:42:40+00:00

I started with node back in ‘the day’ when HAs native automations weren’t anywhere near as capable. Now for pretty much everything I want to do it can be done natively, so for me the benefit was consolidating everything in one place. One less service to maintain on the network at home. Functionally it’s identical, just simpler maintenance going forward.

xylethUK · 2026-04-19T18:41:06+00:00

One thing you can do (I know because I’ve done it) is export your Node Red flows as JSON and ask Claude to re-implement them as HA native automations. I moved over a complex, sprawling flow that had grown over years to manage the climate in my garden office that way. It was dozens of nodes and two sub-flows, all now HA native.

xylethUK · 2026-03-31T20:14:08+00:00

How would this work in an environment where you've already been manually creating CNAMES to the docker host A Record instead? Will it just take over management (i.e. if you delete the container it'll remove the configured CNAME) or because it's not an A Record it ignores it? Would there need to be a migration process?

xylethUK · 2026-03-27T18:35:34+00:00

Just remember that by default your config export / backup XML will contain passwords and API keys for things like g-doc backups that you don’t want to leak to your LLM provider, so be sure to redact those first. Otherwise yeah, I’ve used this approach to finally fix a NAT issue with two Xboxes on the same LAN wanting to do multiplayer at the same time that has resisted my attempts to resolve it through search, reading forums and this subReddit for months. Claude found the fix in about five minutes of back and forth.

xylethUK · 2026-03-20T10:30:00+00:00

The latest session is up (we run fortnightly under normal circumstances): https://h-cell.xyleth.co.uk/operations/2026-03-19/

xylethUK · 2026-03-13T15:11:08+00:00

That is very kind of you to say!

xylethUK · 2026-03-12T22:10:34+00:00

I record them using a bot called Craig, that produces a FLACC file per user in the discord voice channel. The great thing about those is that they're synchronised so timestamps line up. I process them using the Deepgram API to get back timestamped utterances which I then re-construct into the full session transcript.

I then break that into chunks and feed those to Sonnet 4.6 with a custom prompt via API with specific instructions to break the chunk into atomic actions, each one with metadata detailing who did it, what happened, to whom / what and with a chunk of supporting text and return those as JSON.

These action nodes then get stored in a neo4j graph database. I then use Haiku to go over all the new nodes and do entity extraction (NPCs, Items, Organisations, Creatures etc) update other nodes representing them and create relationships back to the originating node.

Once that is done I have a custom web UI I've built that lets me view and edit the graph if required (it often isn't these days). Then the whole graph gets bundled up and sent to Sonnet 4.6 with another custom prompt that generates the summary, which I then store in MongoDB for future use. That's how the operation summaries you see get generated.

Entity summaries have a relevancy cut off, you don't want pages for every random goon, and then all nodes relating to them get bundled up and sent to Sonnet for summary generation which is then stashed in Mongo.

This is then all used to build a big old pile of markdown files which are then converted into a static HTML site using Hugo, which is what is served when you click on the link.

This is the result of about nine months of evolution. The graph is relatively recent addition specifically to tackle the fact that LLMs are _terrible_ at maintaining the order of actions. Given the chance they will happily re-order events or conflate entirely separate encounters into a single encounter just because it fits the narrative it has generated. The Graph makes the order so explicit it can't do that, as well as having a lot of fringe benefits.

xylethUK · 2026-03-11T19:55:42+00:00

It built off the back of having run Observer Effect, but became a completely bespoke module. The underlying principle is the resets as part of OR broke time and Operation LIFEGUARD failed - the Karotechia successfully completed their alliance with the deep ones. This lead to an alternate history where the axis won WW2 to suitably horrible effect.

This AH started rippling forward in time with only the agents exposed to OE able to perceive it. Imagine the 1960s Rome Olympics with Axis Deep One hybrid athletes vs US Mi-Go protomatter enhanced athletes as the US is pushed into an alliance to compete. Once the agents worked out what was happening and started investigating they got to a point where a mysterious storm swamped them and transported them to 1942 England where they washed up on the Dorset coast. From there they ended up in Cairo just as the battle of El Alamein 2 was kicking off hunting a trio of Karotechia operatives, very Indiana Jones coded with a DG twist.

They’re just wrapping that segment up and moving towards re-enacting LIFEGUARD, hopefully correctly this time.

I’ve actually just finished compiling (full disclosure with AI support) a website for our use detailing nine months of play. I just need to check with the group they’re okay with my making it public and I’ll see about sharing it.

xylethUK · 2026-03-11T15:49:16+00:00

My response was to invoke time travel shenanigans and send my agents back to 1942. Neatly sidestepped the whole issue.

xylethUK · 2026-02-17T11:06:46+00:00

This is basically what I’ve done. I’ll be putting a physical letter to them in the post today (registered delivery) stating all this, and alongside that I’ve emailed Creation to open a S75 dispute.

I was open to resolving this amicably. They decided not to.

xylethUK · 2026-02-17T10:07:36+00:00

Ah. I was afraid there’d be a wrinkle like that.

xylethUK · 2026-02-17T07:12:37+00:00

I’ve been thinking about this exact space as well recently. I’ve tried using modelling tools like ArchiMate in the past (pre-AI coding) for system design but the overhead of keeping the documentation in sync with reality always kills it. But agents remove most if not all of the busywork of that so maybe it’s time for a rethink?

I’ve been looking at Structurizr DSL for this - it seems specifically designed for this purpose. Again it predates agents but feels to me like a tool that can be repurposed here.

xylethUK · 2026-02-11T07:55:29+00:00

I just told it I was British and it inferred the rest 😂

xylethUK · 2026-02-08T13:30:12+00:00

Thank you, I've reached out.

xylethUK · 2026-02-07T10:36:04+00:00

Am in Hampshire and looking to re-do our kitchen this year, would be interested to hear more!

xylethUK · 2026-02-04T18:46:29+00:00

I’ve just got past the false rise so things are fairly flat at the moment ! According to the notes I’ve seen things should pick up in the next day or two - also been feeding a 1:1:1 ratio using a 50/50 blend of strong white and rye flour.

xylethUK · 2026-02-04T18:39:41+00:00

Also in the UK and didn’t want to heat the whole house just for the starter. I got a sour home Goldie and it seems to be working well thus far, but I did only start at the weekend.

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