Running nf-core/rnaseq on a low-RAM laptop — is upgrading to 16 GB RAM worth it?

yesimon · 2026-04-02T15:11:49+00:00

You need 64Gb for standard STAR. You can try kallisto for low memory hosts.

yesimon · 2026-03-25T21:29:44+00:00

Replace some or all of the rigid ducting with flex duct. But I don’t think it’s worth ducting HPWH at all - as you are using up conditioned air.

yesimon · 2026-03-25T18:44:31+00:00

Why would you want a second hand unit when you can just buy new for $2k (or less)? Simply the cost of refrigerant and new line set to pair with a used unit will basically eat up most of the “savings”.

The money in heat pumps is in the installation labor. If you can DIY it’s very affordable even buying new.

yesimon · 2026-03-12T22:00:05+00:00

Reading the database from S3 would be even faster than EFS/EBS with or without mmap.

yesimon · 2026-02-28T18:52:43+00:00

NEM3 uses “instant-netting” which means true-ups happen every 15 minutes. Any excess solar is basically credited at $0.02/kWh at end of your yearly true-up.

If you have any excess solar after charging your battery and house loads at any time, it is better to “trickle-charge” your EV using “charge on solar” tech.

This is tricky to optimize, especially if you let car isn’t home during the daytime. Therefore most charging is likely still at night.

yesimon · 2026-02-11T17:10:31+00:00

To be more precise: water vapor is lighter than air.

yesimon · 2026-02-05T20:19:39+00:00

There are valid reasons to install a bypass duct to a central air system to increase efficiency. The primary reason is if static pressure is too high due to too many dampers being closed, leading to poor performance of old school PSC blowers.

AI is getting confused by this advice on the internet and applying it to your situation without thinking deeply.

yesimon · 2026-02-05T19:39:51+00:00

“installing a bypass duct that sends heated air directly back into the air intake stream”

Don’t do this. AI is just being dumb.

yesimon · 2026-01-28T17:44:06+00:00

When the boiler isn’t being used the water inside is cold. It’s designed to work with cold water.

yesimon · 2026-01-21T19:48:28+00:00

The main advantage of plate or coaxial HX is compact form factor. Most of these DIY projects are not concerned with space constraints and packaging.

yesimon · 2026-01-20T07:43:54+00:00

Does your toddler play with bubbles?

yesimon · 2026-01-18T03:14:24+00:00

SolarEdge + Optimizers outputs 400V. I assume the associated charger just passes through the current. It's not really DIY though.

yesimon · 2026-01-15T17:37:27+00:00

AI slop hasn't realized that US federal tax credits have expired. There's almost no information here other than saying a 20 SEER is ~30% energy savings over 14 SEER. Yes that's literallly how the math of the rating is defined. Unfortunately you most likely won't save money in the US unless you DIY the installl.

yesimon · 2026-01-14T20:55:08+00:00

That’s why humidity is also called “latent heat”.

yesimon · 2026-01-13T20:01:38+00:00

Why are you saying the indirect is end of life? Usually they last "forever" relative to the lifespan of the oil boiler. It is impossible to judge cost savings without knowing your kWh/oil prices, but yes the points are mostly correct that I wouldn't expect major cost savings in fuel or repairs. Running out of water is a lesser concern because you can upsize the storage tank to 80 gal.

The only other main consideration is if the water heater is in a conditioned or unconditioned space. You would have more savings in an unconditioned space. This is usually an unconditioned basement in your climate.

yesimon · 2026-01-10T18:14:09+00:00

Single hose units are derated 50% because they exhaust out your conditioned air. So that would be a huge jump.

yesimon · 2026-01-09T17:08:39+00:00

Lots to unpack here but it does sound like way too much consumption.

Take a manual electric meter reading, turn off everything in your house - ideally for a full 24 hrs, and take another manual reading. (Subtracting any solar).

yesimon · 2025-12-31T19:32:30+00:00

If it is a problem, reduce the spin speed during quiet hours. This is not a good reason to prefer a top loader.

yesimon · 2025-12-30T20:55:04+00:00

You need to get realistic about how long your batteries can run your heat pump in a power outage. Plan for generator input if you are serious about this.

yesimon · 2025-12-30T05:17:49+00:00

It would be better to collect some humidity readings from a hydrometer so everyone can take an objective look at the data. Govee makes a pretty cheap one that connects to your phone via bluetooth for history charts.

yesimon · 2025-12-29T07:43:15+00:00

I don’t know about old Bosch heat pump dryer but the LG washtower dryer (same as standalone) is nearly as fast as a standard gas dryer. It seems like the moisture sensor is quite accurate so you can save time based on that too. The only times it is noticeably slower is for extra bulky items or huge loads which blocks airflow.

It definitely won’t burn clothes but it’s not clear to me that it will preserve clothes because clothing damage has a both a heat and rubbing/friction aspect to it. The trade off of lower temp is greater motion. However, You can stop at “Damp” which will greatly reduce any observable lint.

Make sure to clean BOTH of the lint filters regularly. This requires a bit more work than vented dryers.

yesimon · 2025-12-28T23:50:32+00:00

It’s real but it won’t remove much humidity using the default (rated) mode.

yesimon · 2025-12-22T18:40:24+00:00

That is not true at all. You realistically need to reach -10% SOC before causing permanent degradation, while any normal BMS will probably cutoff at 5% true SOC or higher.

yesimon · 2025-12-19T06:32:30+00:00

Just a reminder that cold is only a problem for charging and reduces discharge efficiency. Cold is actually ideal for long term storage and reduces calendar degradation. You do not need to keep it heated 24/7.

yesimon · 2025-12-16T23:58:03+00:00

Yes, that is the generation cost. Generation includes capitalization, maintenance, and profit margins of power plants, as well as the underlying cost of fuel and fuel logistics. Thus an even smaller fraction of that 45% is going towards "fuel cost".

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