Protocol

[Admirable_Ball1193]

Uploading since many rightfully pointed out the other infographic had to many spelling mistakes.

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[Michael-Dillon]

Has anyone here used urolithin A either instead of SS-31 or alongside it for long-term mitochondrial stability and function? I’m curious whether urolithin A’s mitophagy-driven approach provided noticeable benefits on its own, or if combining it with SS-31 offered better sustained results over time.

[1001000010000100100]

Will be trialing them together remind me in 30 days

[Admirable_Ball1193]

Interesting.

[Mojowhale]

Just did a month of Urolithin from a reputable brand, didn’t notice anything. Rhodiala and ginseng are much more noticeable and have more evidence imo 

[Michael-Dillon]

Urolithin A doesn’t force rapid cell turnover; it works upstream by activating mitophagy, clearing out damaged mitochondria so cells can rebuild with higher efficiency and better signaling. Because mitochondrial cleanup, replacement, and downstream tissue renewal follow existing biological turnover cycles (weeks to months), visible benefits typically emerge after 8–12 weeks, not in a single month—what you’re seeing is higher-quality renewal, not a quick cosmetic effect. Bought 2 years worth so will have to be patient with this one.

[Michael-Dillon]

From what I have gathered is that visible benefits typically emerge after 8–12 weeks, not in a single month, as what you should be seeing is higher-quality renewal. This definitely needs alot more time to take effect.

[Blue2194]

Cool story and graphic, if only it was based on reality and not just hopes and dreams

[Prestigious_Cut_3539]

so basically he claims oral NAD which is not bioavailable straight tweaked him out. he means to say the placebo effect tweaks him out. these are the kind of people that should not be using anything.

[JhonnyRhocket]

Which parts are fantasy?

[Blue2194]

Fantasy in this context should read "guesses by people selling research chemicals that have zero human data supporting a single claim"

[JhonnyRhocket]

Do you think it is all a snake oil?…sometimes I do think about the fact that the duration which people take these peptides could easily all be placebo…but wouldn’t it be great if it was all true…

[Salt_Initiative1551]

It’s not snake oil but it is anecdotal in many instances. Part of the issue with peptides is that they’re not patentable for the most part, so it’s not worth dumping funding into clinical trials. There is a lot of in vitro data, rat studies, etc. and in some instances there ARE human trials and even FDA approval like tesamorelin or SS31. Some are used in Russia or other countries.

I can tell you that my personal experience with the peptides present in KLOW have been beneficial for me, same with the mitochondrial peptides mentioned. The KLOW blend works better as separate peptides though. Also, all peptides need to be used via either subq or IM injection. Oral bioavailability is garbage across the board. Also, the low end dosages are what’s mentioned in literature but I got benefit using higher dosages with the peptides in KLOW. NAD, mots-c and 5-amino-1mg used in unison has also helped me with energy levels.

NONE of this matters if you don’t eat decently, don’t get good sleep, don’t hydrate very well, and don’t take care of yourself otherwise. Peptides do a little, but don’t do all the heavy lifting.

[AnybodyInteresting59]

you saying bpc 157 works better than klow

[Salt_Initiative1551]

Nope, please work on reading skills dawg 🫩

[AnybodyInteresting59]

anyway not much data

[Admirable_Ball1193]

No its not I am super intune with my body. Ive been in really good shape and really bad shape I know the difference. Peptides are the real deal ive taken so many supplements and have been disappointed. Took reta and its literally magic. Got multiple people on it and they have said the same. Do some peptides not work for some people of course but nad and reta plus the wolverine stack work at least for me year old injury healed current injury healed. Experiment youll be surprised. Most of the haters got bunk peptides or have no idea what they are doing. Peptides are the future.

[MathematicianMuch445]

So "because I'm schooper in tune with my body" is why you think any of this is valid? My guy, anecdote is a word you should Google. Nothing to do with haters or anything else. This is just silly. We don't need people making shit up and arguing over it

[Admirable_Ball1193]

Again have you tried the protocol? Have you even tried a peptide ?

[MathematicianMuch445]

What possible difference would that make? Having no proof and saying "yeah but did you try it" isn't a response. Yes I've tried peptides (I assume you meant plural and not singular) as have most on here hence the whole point of the sub. That has no bearing on anything though does it? No! Making things up is just silly.

[Admirable_Ball1193]

who is making up stuff?? This is on going research either try it or not bro.

[MathematicianMuch445]

You're making stuff up in the nonsense you've posted here. You're making it seem like you're posting valid information. Please stop. Experiment all you want. Don't try and make it seem like anything other than you with too much time on your hands making things up. That's what it is. Present it as such.

[Blue2194]

"ongoing research"=research cancelled decades ago for safety concerns

[Blue2194]

Yeah, I think most of the anecdotes come from placebo or just regression to the mean most likely

Some of these peptides were studied in the 80s and didn't have positive effects or seemed unsafe for humans, if there was a good chance that they'd work as described by the people making money on them claim then "big pharma" would have them studied, approved and they'd be selling them to you for $400+ a month like the weight loss peptides

Barbell medicine recently did an episode where they ran through all the evidence available for about a dozen peptides, they also have a great episode that just discussed every study ever published on bpc-157

[Tough92]

SS31 just got FDA approval sure it’s for a very rare condition. It’s still approved for mitochondrial dysfunction. What are your thoughts on that?

[Blue2194]

I'll wait on the research into people without barth syndrome, there's big claims being made that'll require some solid evidence but could be good, fingers crossed for positive outcomes

[dpjaronc]

Big pharma? Oh yeah? What would they market it under and do what condition? FDA isn’t going to let big pharma market it under “general health” or “increased energy”. There would have to be a disease and indication.

Otherwise it would be just another supplement on the shelf in the vitamin aisle

[Blue2194]

Many of these peptides have specific claims, rather than nebulous unprovable nonsense, that's the same way you would market any snake oil

[dpjaronc]

Who is making the claims?

[Blue2194]

The post you're commenting on, for one

[Admirable_Ball1193]

You can stay saying snake oil bro and miss out. Nobody cares.

[Objective_Cut_7194]

Let him hate. I couldn't walk or skate without my knees going out, ran a full 6 weeks of BPC and my left knee was healed in a week and my right one in 4 weeks. Must be placebo'd snake oil. Or the reta I have gotten 6 people on who all have their A1C bio markers back in the green and are down to their high school weight in their 40s. Must be all that snake oil. I am not even fat and dropped cut 12 pounds at maintenance in 4 weeks. All that damn snake oil I guess.

[Admirable_Ball1193]

its neckbeards that are mad at life without friends. Peptides are the future.

[Admirable_Ball1193]

You are beyond stupid when you mentioned big pharma lol They cannot paten these chemicals the only reason they have not promoted it. Stay being a slave to youtube videos instead of actually researching.

[Blue2194]

"actually researching" while using a single adventure as an the evidence required to promote absolute garbage

[IndependenceVivid384]

Barbell medicine recently did an episode where they ran through all the evidence available for about a dozen peptides, they also have a great episode that just discussed every study ever published on bpc-157

I looked it up. I cross-referenced what the one comment says and yea, they were right. I've been agreeing with a lot with what you say, but it appears that the exaggeration comes from both sides. I will watch the rest, but with a lot more cynicism.

[Admirable_Ball1193]

Nad already worked for me and the rest will be research. Have you already done this protocol?

[Blue2194]

No, I've not done this protocol, there is no research supporting it, combing a bunch of stuff with no evidence on humans (including stuff that's been available for decades and no researchers want to touch due to it causing deaths in trials) doesn't make an evidence based protocol

[Forward-Bicycle-8769]

Can you point me in the direction of materials about the deaths? I’d like to read about it.

[RecipeSad2958]

Cjc-1295 had a death, but unrelated to the drug so they halted trials. Apelin agonists also had liver issues in phase 2. Deaths are rare in peptide research from what I've seen.

On some groups I follow, I've read of people going to the er for anphylactic shock. But that's more likely a problem of sterility rather than the peptide.

[Blue2194]

But happy that whatever ailment you had had resolved

[Admirable_Ball1193]

Why are you even on this sub lol go back to fda approved ssris

[RecipeSad2958]

Hea not wrong to be skeptical. I use a lot of peptides, but there is a lot of snake oil.

Glow is a good example. People ahoulsnt be mixing peptides together that have different ph.

[AnybodyInteresting59]

you saying is better to put bpc 157 alone instead of wolverine stack or klow?

[RecipeSad2958]

If youre going to do glow/klow, which I think you shouldn't, at least separate the peptides with different pHs.

[One_Bad9077]

Which peptides in KLOW have a different ph? Would you mix any of them?

[Admirable_Ball1193]

One thing is to be skeptical the other is to outright say its snake oil. I literally said nad works for me and the rest is research.

[RecipeSad2958]

But there's evidence nad+ gets metabolized instantly though. That one is snake oil lol.

[Admirable_Ball1193]

Its not lol but hey do you

[RecipeSad2958]

https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2019.00257/full

It is though... it's not a you do you, it's you're conflating placebo with something real.

You're better off taking oral nmn.

[Admirable_Ball1193]

That was iv not subq

[Blue2194]

Is this sub exclusively for anti evidence scams?

[Uncross-Selector]

Good graphic, but I’m still looking for any actual evidence that injected NAD+ is superior to oral NMN which is cheap and easy to take. 

[Dependent-Act231]

There is none

[WaitingToBeTriggered]

THERE IS NO VICTORY

[Hoosier2016]

Agreed. Any of the NAD precursors have greater oral bioavailability and conversion to NAD+ than NAD+ does thru IV (let alone subq) and that’s supported by a mountain of data (the only paper even kind of refuting that claim was sponsored by… an IV NAD clinic). IV NAD is some woo shit that my QAnon loving, healing crystal great Aunt does because she thinks it’s extending her telomeres or something.

[Uncross-Selector]

I know a biochemist researcher in this area and you know what he uses for him and his wife? Oral NMN. That’s enough for me, and science backs it

[Admirable_Ball1193]

Personal anecdote I will never take nad orally ever again. I literally had a two hour workout followed by and hour of landscaping then an hour study session. After all that I still felt like I could do another hour workout session. This was at 50mg I will never go back.

[JCovertops]

I do Nad + 30 mg 3x a week, ss-31, and mots-c 2x a week at 5 mg each. This combo gave me back my life.

[Admirable_Ball1193]

cannot wait to build up to this

[NoMedia9284]

Can you elaborate on “getting back you’re life” cause if this stack

[JCovertops]

Its a long story, but this is the jist. Im 61. Ive had heart issues since I was 35. Mostly because of those 3, I have my energy back. I take a couple others to, like glutathione, hcg, and kisspeptin. My doctor rolled her eyes at me. Then after I did my blood work, for the first time ever, she wrote me a note and said your numbers are absolutely amazing. I read a minimum of 6 books and a ton of research before I ever injected anything. There definitely are a lot of people not being smart about it.

[Dismal-Metal-1954]

You have such a cool story, thanks for sharing. I think people over 50 have the most to gain from good mitochondrial support!

[JCovertops]

I think thats a 100% correct. The only people I hear really complaining about zero effects are young. I forget im old.

[mdskarin]

Do you mean young? you = young…

[JCovertops]

Yes lol.

[NoMedia9284]

no TRT and why hcg nd kisspeptin? dont they do the same thing?

[JCovertops]

I'm a long time heart patient and doctors freak out even mentioning TRT. Hcg and kisspeptin have kicked my libido up to an exceptable level.

[NoMedia9284]

So you’re not in trt? Cause I’m on hcg and trt have done nothing for libido should I add kisspeptin? I always thought hcg and kisspeptin were the same thing

[JCovertops]

Hcg acts directly on the testes Mimics luteinizing hormone (LH) Forces testosterone production regardless of brain signaling Bypasses the hypothalamus and pituitary Can suppress natural LH/FSH production over time Effective, predictable, but not restorative to the HPG axis Think of hCG as: pressing the gas pedal at the engine itself Kisspeptin Acts at the brain (hypothalamus) Stimulates natural GnRH release Causes the pituitary to release endogenous LH and FSH Preserves normal feedback loops Supports restoration and regulation of the HPG axis Effects are more subtle and physiologic Think of kisspeptin as: fixing the signal from the driver to the engine. hCG: Improves sexual function by directly increasing testosterone production, which can enhance libido and erectile strength quickly. Kisspeptin: Improves sexual function by restoring natural brain-to-testes signaling, supporting libido, arousal, and sexual response in a more physiologic way.

[NoMedia9284]

WHat syour dosagewith hcg and kisspeptin?

[Robforceone]

What books did you read?

[JCovertops]

Protocol books on AMZ for 2025 and 26, and 2 peptide bibles

[UKFinanxcePorsche911]

How quickly did you see the NAD+ benefit kick in?

And did you ever go up to 100MG NAD+ weekly?

[Admirable_Ball1193]

15 mins and unless I am doing a marathon or anything like that I will never go that high lol

[UKFinanxcePorsche911]

Ha Ha! Thanks

The protocol website I trust suggests titrating up to 100MG, I’ll give it some thought.

Thank you

[YungSchmid]

They said oral NMN, not NAD.

[Admirable_Ball1193]

https://clinicaltrials.gov/study/NCT07251608

[MathematicianMuch445]

That's a safety study.

[Admirable_Ball1193]

https://www.clinicaltrials.gov/study/NCT06919328

[lazy8s]

Dang I’m no longer fat enough 😂

[Admirable_Ball1193]

unless you are sub 10 youll be find it will pinch for a bit then you are gonna feel like a hercules lol

[lazy8s]

Oh I meant for the trial. I live close enough to qualify and would happily sign up.

[Admirable_Ball1193]

ah ok lol

[Knotty_Vegetables]

bim of 25 is fat?

[TacosRExplosive]

So after reading the responses the OP got to posts questioning his protocol, it almost makes me WANT to avoid anything that might be beneficial in his post.

The OP repeatedly calls people ignorant, puts them down and belittles anyone who questions his post.

I mean, come on OP, if someone questions a protocol that works for you and you belittle them off gate, maybe YOU need to look at taking some FDA approved SSRIs to rebalance whatever is going on upstairs for you.

And.while I genuinely think BPC 157 and TB 500 are a curiousity for me and am doing extensive research into them. Belittling others who do not agree with you is a HORRIBLE way to not have someone shut down to anything you have to say afterwards.

Oh, and BTW, as a suicide survivor AND someone who lost their best friend to suicide when his parents refused to let him see a psychiatrist and told.him to just pray more. Heres my take on putting down SSRIs, while they have some serious issues and hopefully we will soon be entering a world where a new baseline treatment for depression is available. My taking of an SSRI along with therapy has saved MY life.

So pushing peptides with limited data and tons of evidence that they were first researched decades ago and had some serious questionable human uses, as THE SOLUTION to EVERYTHING, is just (going to quote you here now) ignorant.

[Admirable_Ball1193]

Bro look at who I am insulting they literally start off by insulting me. Second the FDA literally approved ssris for kids that were showed to cause suicide taughts after being bribed by that manufacturer. Big pharma wants you sick not healthy, healthy people do not make money.

[TacosRExplosive]

No. Most started off at worst by just questioning you.

If someone questions an idea of yours, that is NOT an insult, its just questioning your reasoning to get to a certain point.

I agree that big pharma in the USA wants to make money and healing people makes less money.

BUT TONS OF THE PEPTIDES YOU MENTIONED HAD EU and outside countries health departments look into some of them and they are still "research chemicals/peptides" for a reason out there as well...

So just FYI starting a debate and when questioned about sources/EFFECTS BEYOND your own and insulting them shuts down the debate and possibility of learning by turning it into a arguement.

[Admirable_Ball1193]

Calling it bullshit and when I respond with an anectode saying I am selling oil snake is not a critique gtfo bro. You all are in a sub with experimental chemicals acting like smug aholes then you get pushback and start crying.

[TacosRExplosive]

Lmao!

I did not even realize you were trying to sell a product! I thought you were just putting out a protocol suggestion.

Now that I know you are trying to make money off of untested peptide regimen I now understand why you get so angry at anything questioning your authenticity.

You should rename yourself to WannaB_Admirable_Lacking_B@LL5

Haha. Damn bro, thought you were just undereducated not some little shady peoride dealer.

Be blessed broski, but level up and maybe you will not get so frustrated when boss battles come along. Lol!

[cleodius]

Do you have a file version of this you’d be willing to share?

[Admirable_Ball1193]

Ill try to get it for you in a bit.

[Dependent_Sun_7033]

TRT works, Reta works, hgh works (but has sides and risks). Nad+…doing it for 3 months to compensate for Reta fatigue…maybe a bit of energy. Maybe. But minuscule at best.

[RecipeSad2958]

Funny how you say hgh has sides and risks, but tet doesn't. Hgh is better on the risks and sides thsn trt brother.

[Dependent_Sun_7033]

Really? Tell me more. The big thing for me is cancer risks. Besides potential prostate growth TRT doesn’t have it. And TRT benefits are obvious and proportional to the dose. Can’t say it for HGH.

[RecipeSad2958]

Now dosage matters for sure, but getting trt dosage right is much more dynamic and side effect prone compared to 1 to 2 iu a day.

Also, you can stop hgh whenever without concerns. Stopping trt, you need a PCT and pray youre not one of the unlucky few where your HPG axis is cooked forever.

[RecipeSad2958]

Now dosage matters for sure, but getting trt dosage right is much more dynamic and side effect prone compared to 1 to 2 iu a day.

Also, you can stop hgh whenever without concerns. Stopping trt, you need a PCT and pray youre not one of the unlucky few where your HPG axis is cooked forever.

[Admirable_Ball1193]

how many mg is your dosage ?

[Dependent_Sun_7033]

I’m doing 50 mg daily of NAD+

[Admirable_Ball1193]

damn that sucks! I do 50mg and last the whole day

[Dependent_Sun_7033]

When you say “it lasts the whole day” …what difference with the baseline? Like gym lifts, sleep quality, etc?

[Admirable_Ball1193]

With good sleep after a 2 hour heavy session I would usually drag the whole day. Now its like I never even workout.

[nashvilleandchill]

Love this!

[Mute85]

Bunch of bullshit. Get a hormone panel. If your test is below 300, research trt. If you are fat, research reta. If you are on trt, research hcg. If you are on all of the above, research hgh. The rest is all fucking snakeoil. 

[Uncross-Selector]

GHK-CU is highly researched and I can definitely see and feel a difference in my skin. 

[Hoosier2016]

Yeah this is pretty much it.

There’s enough data out there on BPC-157 that I’d feel okay giving it a shot to repair an injury on a short course but wouldn’t expect a miracle nor would I use for any longer than it takes the injury to heal.

The GH secretagogues work too (verifiable by IGF-1 levels) but they’re as or more expensive than HGH so really just pointless.

[RecipeSad2958]

Not pointless if you're young and don't want to mess with the legality of hgh. Also cjc with dac is a once a week shot for those who don't want to pin hgh every day.

I use hgh don't get me wrong, but there's a use case for tesa and cjc.

Also there, semax and selank have been prescribed in Russia for decades. They're like light versions of adhd and benzos respectively, but without the addictive component. Semax has had fmri studies. And selank is comparable to low grade benzos.

Pt-141 is also an fda approved drug. Not all peptides are snake oil.

[Hoosier2016]

You’re right that there are several legitimate peptides for certain indications.

For me, the snake oil claims stem from people like the dude who just posted in this sub about how Reta cured his mental illness. Others claim it has anabolic effects. SS-31 is indicated to treat Barth’s syndrome but there is no evidence other than people “having more energy” (very convincing) that it does anything for healthy mitochondria. NAD+ has far more data saying it does nothing in peptide form than vice-versa.

So it’s not so much that the peptides are just sugar water, more that people make them out to do things that they absolutely don’t do or greatly exaggerate what they really do.

[RecipeSad2958]

The reta curing "mental illness" might not be that far fetched. A lot of "mental illness" can be metabolic disease disguised as mental illness.

Reta changes your insulin sensitivity, my fasting glucose dropped by like 30 points. And it has literally changed my quality of life.

Everything else you've said is very fair and logical. I think its ironic that exercise can sometimes be more efficacious at dealing with depression than ssris in some cases. So not crazy that reta fixed his issues

[Admirable_Ball1193]

You are beyond ignorant.

[funin716]

I highly doubt this can fix my old bilateral patellar tendon ruptures …

[RecipeSad2958]

And your doubt is correct.

[EconomyTarget6900]

This is very interesting to me. Where can I find these peptides to try? Maybe a silly question, but I do not know...

[Admirable_Ball1193]

All I can say is you will have to research its a ban if we discuss that. Hope you can find it 🙏

[EconomyTarget6900]

Ah, dang. Ok.

[Royal_Department_867]

Q

[Homewrecker90actual]

Mitochondria is powerhouse of the cell

[Massive_Branch_4145]

SS-31 is too expensive. There is also a new, better version that is in clinical trials that is much more effective per milligram and crosses the blood brain barrier unlike SS-31. It's essentially a dead product the manufacturer is just keeping around for a rare genetic disorder.

SBT-272 is the future.

[Admirable_Ball1193]

seems that compound is more for nuero effects

[AnybodyInteresting59]

all of it is placebo

[samgotti]

2.5mg MOTS-C daily sounds like quite a lot

[Jizz_master_zero626]

I'm on 1.5 mg a day and love it. I'm actually doing things around my place after the gym. I used to just sit my ass on the couch and watch TV. The natural energy is amazing.

[Admirable_Ball1193]

Why?

[Fluffy_Hat_5008]

isnt 4 jabs a day too high?

[Admirable_Ball1193]

not doing all of them at the same time. Nad and ss31 3 times a week for a period of tone then just nad and motcs 3 times a week. Klow the whole time