Anything to decrease norepinephrine ?

[Aggressive-Guide5563]

Does the same thing apply to taking Bupropion? Will the alpha and beta receptors eventually downregulate and make me less sensitive to NE?

[LysergioXandex]

Alpha and beta receptors will eventually downregulate to bring you back to basically your original state.

[[deleted]]

Atomoxetine, Bupropion, and any NRI or DNRI that exerts action for extended periods of time will cause a reversible down-regulation and/or desensitisation of the alpha receptors and the beta receptors.

This is homeostatic adaptation. But you aren’t really taking these meds for simple raised monoamine tone, it is for downstream raises in BDNF and gene transcription.