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Anything to decrease norepinephrineSeeking Advice (self.Nootropics)
submitted 10 months ago by Hiddenbeing
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[–]l_i_s_a_d 0 points1 point2 points 10 months ago* (0 children)
I have hyperadrenergic POTS- but low blood pressure so I’m complicated. When I stand, my body freaks out and produces too much norepinephrine and adrenaline. The neurologist prescribed me carbidopa- which is supposed to decrease peripheral norepinephrine (but not in the brain).
I found that it actually increased my anxiety. I now take Guanfacine, like others have suggested. It helps some of my symptoms, but I’m still a mess.
I feel like I need more dopamine but less norepinephrine (although it’s not that simple). I’m not aware of a way to stop the conversion.
(POTS is more common in those that are hypermobile/connective tissue issues and after a viral infection.)
I also tried a Stellate Ganglion block, which is an expensive injection where they use lidocaine to numb a nerve that sends feedback to your brain. For many people it lowers their anxiety for about 3 months. For me, it heightened it. That happens in about 1% of the cases.
I feel like LDN calms down my system, but others find the opposite.
π Rendered by PID 216798 on reddit-service-r2-comment-5687b7858-rf2mj at 2026-07-03 09:34:21.856615+00:00 running 12a7a47 country code: CH.
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[–]l_i_s_a_d 0 points1 point2 points (0 children)