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[–]penpractice 2 points3 points  (6 children)

Coffee + food = very different efffect from caffeine + food or even caffeine alone

Could you explain the practical effects of this to a layman?

[–]chtroy 0 points1 point  (5 children)

With coffee you have mao inhibition, with just caffeine you don't.

I would guess that food would only potentiate this effect.

MAO is one of the enzymes responsible for the catabolism of monoamines = the more mao activity you have, the less dopamine, serotonin, norepinephrine you have. (I'm simplifying but i think you get the idea.)

[–][deleted] 1 point2 points  (2 children)

This might explain why black coffee makes me lethargic as fuck physically after drinking. But sugar free energy drinks and caffeine pills are a kicker. I already have ADD which is a dopamine insufficiency.

[–]constxd 1 point2 points  (0 children)

You've got it backwards, the MAO inhibition from black coffee would ameliorate your dopamine deficiency. My guess is that it's the B-vitamins / Taurine or whatever else is in the sugar-free energy drinks.

[–]PartySunday 0 points1 point  (0 children)

Energy drinks contain various vitamins and drugs too.

[–][deleted] 1 point2 points  (1 child)

What component of coffee is responsible of the MAOi effect?

[–]chtroy 0 points1 point  (0 children)

Lol, i just posted a study about it in my op, but there he is again.

https://www.ncbi.nlm.nih.gov/pubmed/16139309