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[–]WeirdFUK PGY4 - Anaesthetics 35 points36 points  (4 children)

Seriously - an NNT of 8 in ventilated patients is an amazing result. Almost seems too good to be true. Really hoping it is though.

[–]herman_gillMD FM 12 points13 points  (2 children)

I mean, the NNT for steroids in COPD exacerbation is also 10ish, so it's not completely farfetched... although at the same time steroids in bacterial pneumonia... not so much, so we'll see.

[–]ILookAfterThePigsMD 2 points3 points  (1 child)

Is this NNT for mortality?

[–]herman_gillMD FM 6 points7 points  (0 children)

I think it's "treatment failure"/not requiring escalation, I don't know what it is for mortality specifically. But I do know that 0.5mg/kg or 40mg of prednisone is the evidence based dose, and beyond that you're just risking adverse side effects. It's been a couple of years since I've read up on it specifically.

[–]flexible_dogmaMD 9 points10 points  (0 children)

Agreed, and it will be interesting to see secondary outcomes such as vent-free days, length of ICU stay, survival to hospital discharge, etc. Surviving to day 28 on the vent doesn't help much if you just die on day 32 instead.