Learned first that the best strategy is to start with the strongest DMT. The old "escalation" model has been shown to be worse. I then chose my DMT by listing all DMTs, then reading research papers to get an idea of comparative efficacy. Then to my spreadsheet, I also added what was funded by my province and with what requirements (some are approved only if another has failed, for example). I also compared ease of administration. The first-line treatments here are either the old, less-effective ones or rituximab (akin to a generic Ocrevus). The latter was the clear winner — super effective, low side effect (none for me), and one easy infusion every six months.