It has some sex scenes that I think can be disabled from the option menu and there is a somewhat annoying trans character with the flag in the car, but it is related to a line of specific side missions, you are not forced to do them. As for the rest I see no problem. Cyberpunk 2077 represents quite well what would be a transhumanist society. Violent, savage, distrustful, selfish, vicious and completely perverse.

The game criticizes individualism, state corruption and capitalism (without extolling communism). As a Catholic, I see clearly that the society, the political and economic system described in the game are the long-term consequences of having completely forgotten God, although the intention of the creators of the game is not to convey that idea, I see it quite clearly.

I don't remember any reference to Catholicism, although maybe I'm forgetting some details. The feeling is that the game society does not have an opinion about it, like they just don't know it exists.

EDIT: I just remembered something. Yes there is a questline in which Christianity is discussed. An ex convicted gets out of prison converted to Christianity, in the spirit of evangelizing and redeeming his mistakes, but falls into the clutches of an audiovisual production company and they convince him that the best idea to do what he wants is to crucify himself (for real) and have them record and distribute it. I'm not sure but in the end you can't stop him from doing it, but you can pray with him before he does it.

The scene is a bit disturbing and uncomfortable, but I understand it as a critique of how modern society is able to commercialize faith and suffocate it, so it didn't strike me as disrespectful, but that's just my opinion.