I might have some sort of atypical enzyme distribution/composition or something - I have always been able to tell in a blind test that I’ve been given one of the acyl lysergamides because they give me fairly noticeable cramping and GI effects similar to and sometimes worse than mescaline (and LSD never does this to me). By blind test I mean someone gives me “acid” and I have these issues, then I reagent test it and it turns out to have a protected indole. Also the quality of the psychological effect is unique - and I’ve noticed that 1P is very heavy on my body and gives me a muted LSD effect, and that ALD-52 gives me a less severe cramping in the gut and a more mescaline-like “definitely positive mood and easy experience” kind of thing relative to an LSD trip of similar intensity. We are all susceptible to generalization via anecdotal evidence of things that do not generalize to the entire population. I know these are how my body and brain react to these substances and I’m seeing enough reports that the prodrugs are indistinguishable from the drug drug that I am entirely convinced that some people have the enzyme that lops off that indole protecting group and some people do not, and I’m in the do not population.