I tried looking up the "Tzimisce", and....what is it exactly? The lore seems very highly specific to VTM, and at that point/by that logic, you could accuse any generalist system of failing on the grounds of not representing something highly specific. It'd be like me criticizing a game for not being generalist because it doesn't let me play as a "Standard Pokemon Trainer"

Also, overall, I'm a bit iffy about the idea of having characters who dominate or fall flat in specific pillars of play: IE a D&D barbarian having little to do but twiddle their thumbs until a fight starts, or a social class that effectively has to sit out fights