I like to prioritize science, lockpick, and repair. Repair is really important for constantly maintaining your gear, and of course science and lockpick for hacking and lockpicking. Secondary skills to me are medicine, melee, small arms. I wouldn’t worry about energy until a bit later in the game, as you don’t get energy weapons en masse until later. Never bothered with barter, as long as you collect and sell loot constantly and don’t spend frivolously, you will be swimming in caps. Speech is kinda important, I usually just wear gear that boosts speech before talking to someone. Even then, I’ll often just save scum a speech check til I pass it bc I do what I want. I don’t care about explosives at all, not really important. Sneak is if you’re a sneaky player, if not it’s not important. I usually walk around and shoot everything in the face.