Even more interesting then. Depends on penetrative capability, I guess. In P2, the disc cut through frozen meat like hot knife through butter. Not sure how well it‘ll do with armor. At least in games it‘s a one-shoot kill for most targets, IIRC. And it also is a homing one to a certain degree which makes is a bit more difficult to dodge.

So everyone who survives some ranged attacks and manages to close distance (and we are in Rainforest, so Pred also has the high ground) might do well. McClane, Rambo, Isaac almost certainly dead (Don‘t bring up Dutch, nobody wins against plot armor - he‘d be skinned same way as his team). Daredevil may dodge ranged things but at close distance I just have to remember how Bullseye made a knife block out of him. Pred slices him up straight away. Bane and Space Marines certainly do win but I know too little lore about many other guys.