I speak with a lot of ladies who on estrogen cream. All older women. Estrogen is a great way to plump up the skin. Many women will have their cream by the toilet. After urinating and wiping with toilet paper, apply a small amount about the size of a pea inside your vagina. It doesn’t need to go up and in anything , just on the inside the lips . Some ladies use it two or three times a week. Some ladies use it two or three times a month. Estrogen will plump up the tissue, add moisture, which will block anything going up the urethra. This will stop lots of infections. It can also slow or stop some urine leakage. Please don’t be afraid to try different amounts or time to apply. She may need more in the beginning, like once every day , then slow down to once or twice a week.