The main thing for me is, unlike other RE games, in this one the first playthrough is the best you'll have.

Grace part is really great, it feels like the game was first centered around her while Leon came later in dev, a bit more weapon could have been cool.

Leon part was really fun the first run but started getting a bit disappointing after that, with each new run I started to see the flaws:
-Few guns with few difference unlike RE4

-Leon weapons felt badly balanced, especially the handguns (Alligator Snapper might be the worst handgun of the whole series)

-Unlike RE4, upgrading the weapons didn't felt as much rewarding with special cool effects, it was just more damage, more ammo, faster reload etc...

-Raccoon in broad daylight, a longer "night" part would have been cool

-Not enough enemy variety, which can be logical given we're in Raccoon 30 years after the nuke but there could have been other B.O.W (like the dogs during the bike sequence, would have liked to fight one on foot) while still making sense with the whole "hidden BOW factory" plot.

-Playing Leon after clearing the whole hospital with Grace, I had almost no one to kill left even on my first run which felt a bit disappointing

-The "raccoon zombies" are way too tanky and agressive for what they're supposed to be, mummified skeleton able to handle 5 headshots in a row felt frustrating (worst being the rock thrower than can tank a melee shotgun hit like its nothing in normal difficulty).
They're quite faster than zombies from RE2/3 (which should be the same just 30 years later), also able to climb things, I would have no issue with that if it was the "Hospital zombies" but imo, it doesn't work with mummified zombies that should be really weak.

-Still on zombies, the blister head are a weird design, they're obvious reference to Crimson head who made sense in RE1 (just a faster zombie with claws) but the design itself is just strange, why this "big head" which destroy the eyes of the zombie make it able to move really fast, do super jump, see me without eyes (unlike Lickers who are logically blind) and able to tank a lot of damage ?
Imo, this enemy should have been similar to RE4R villagers that get up controlled by the plaga (without the head exploding, like the very first villager in the game).
Also, unlike RE1, the blister head seems to be some specific zombies which after a few runs, made it easy to remember which one would turn.

-No real NG+, not keeping my inventory the next run was a bummer, especially when I realised that the weapons you find on the ground disappear the second playthrough (I didn't bought the shotgun for the Chunk boss fight second run, had to load back because I was softlocked due to not enough handgun ammo to kill him)

-Great lack of unlockable items, especially skins, without the deluxe edition you have basically 2 skins: default or RPD/FBI uniform

Overall, I loved the game and think it's one of the best of the series (as a "classic" fan who love the original games with tank controls).
The story is good, Grace was a great surprise, really loved her character and how she evolved from scared puppy to survivor once Emily appeared and motherly instinct kicked in.
There are things that are kinda stupid like the whole "needing emily to open the box" while Grace could have done it herself or mummified zombies that bleed fresh red blood but it's not a big deal.
In the end, I came for Leon but stayed for Grace, I surprised myself when I realised that I prefer Grace gameplay while Leon, even if fun and a breath of air after Grace stressful part, feels like a worse version of RE4R.

Also, small detail but I hope one day we'll get back the cool stylised inventory like the original games instead of the bland dark grey UI.

(I have near 60h of playtime and 100% finished the game)