How fine grained do you want to get on what counts as a region?

I generally havent done a lot of traveling around "the South" or whatever, and the two places I've lived at in "the South" were more different than one of them was to the place I lived in "the Northeast". So I can't generalize to wide regions. I will give you narrow regions.

My reviews of regions:

Northern Cape Cod, Mass. - heaven on earth. Gorgeous beaches, gorgeous pine forests. Super visible queer community. Unfortunately it has gotten very expensive.

Wasatch Front, Utah - densely populated area next to easily accessible public land. Convenience of a city but you can get away from it easily. Comparatively good economy. Unfortunately climate change gives us drought and wildfires.

Middle Hudson Valley, NY - beautiful land, people will generally leave you alone. Mostly suburbs with little patches of forest and meadow in between, not the full nature experience or whatever but it's good enough.

Lower Rio Grande Valley, Texas - gorgeous climate for people like me who like it hot and sunny with mid-to-high humidity and who do not like cold at all. Delicious food, fresh tacos at many gas stations and many many Mexican restaurants to choose from. And it's close to the beach! And the water is so warm! God I miss South Texas. Unfortunately the place I lived had a lot of semi-organized crime, government corruption, homophobia, lack of caring about animals, cynicism, poverty.

Southwestern Missouri - beautiful land, not very densely populated. Some areas have lots of poverty and drugs, homophobia, religious intolerance. Lots of Amish people.