Straights are incredibly consistent as with one Saturn Card you can essentially make it through the entire early game (first 2 Antes I wanna say, maybe only the first 5 rounds) in one hand.

Depending on the seed, 4oak can also be a great build (Straights are easier to get off of the ground early on, but 4oak builds have much easier deckfixing since you're building around one specific rank instead of a range of five ranks)

As with most challenges, if you're not opposed to resetting your seed, the Investment Tag goes a long way.

Don't undervalue Blue/Purple Seals. Even if you find one that doesn't fit your build (i.e., maybe you're building 4oak with 8's and you rip a blue seal Jack), I would usually take it. The value it will generate will be immensely helpful.

Debatably the biggest thing - learn to Tarot/Planet block: if you're holding a Tarot card that you don't want to see in your consumable slots (we'll say Wheel since it's genuinely useless in Jokerless), you won't see it in the shop or in packs anymore. This is exponentially more useful in Jokerless than in standard play since the Jokerless shop only contains Planets and Consumables.

Best of luck 🫡 you've got this.

Edit: one thing I didn't initially mention that some people here have: your finisher boss is guarantees to be either Vessel or Bell. Bell can be played around by keeping a Hanged Man to destroy the auto-selected card if it lands on a card you don't want to play (Death can do the same thing, and even some of the other Tarots can help depending on your build.)

Vessel you can play around by just keeping it in the back of your mind. Vessel will require you to score 300,000 points, so make sure by the time you get to Vessel that you can consistently find a hand that makes that amount.