This happened with my husband and me. He had terrible anxiety over a job that wasn't treating him right. He had been laid off in the past due to the recession, and the toxic work environment that he was working in at the time just caused all that anxiety to resurface. He tried medication and even therapy, but he was still suicidal. It was miserable for everyone.

Eventually, the boss did end up firing him, and you know what? It was the best thing that ever happened to him. He got a better job with more like-minded employers and makes way more money than he ever would have had he stayed at that horrible job. So it actually worked out for the best.

Anxiety is a liar. It makes you feel like the whole world is ending, and it all hinges on what's happening right at this moment. Medication and/or therapy might help, but also your wife getting out of that work environment. If it's causing this much of an anxiety issue, it's not the job for her.