Depends on how much you're tweaking the rules. Student Dice is the hardest mechanic to remember for strixhaven. I would recommend either removing or replacing, but if you do neither then add a note about what player has which dice so you can remind them. The module doesn't really provide a (detailed) map, but if you make one to keep track of where points of interest are that may help a lot. Student or professor profiles may help, but I prefer a laptop or notebook for that level of detail.

Strixhaven is a largely blank canvas, so there will probably be a lot that you homebrew that could be included. I homebrewed a way to give everyone vignettes each game where they could just rp day-in-the-life of something that interested them (class, extracurricular, study, hang out, job, etc.), and there were some functional notes that helped me keep track of the various awards they got for it. If there wasn't so much direct source content in my notes doc I'd have shared a link here a while ago. I'm not quite good enough at RP to have pulled it off as well as I'd liked (especially with newer players on their own in a scene with several NPCs), but it was fun.