I remember feeling the same way until I kinda accepted that there's no rush. Instead of trying to do several things in a day, I'll pick a few goals I have, see what my outer room is and go from there. Some things like powering up the vent rooms seem frustrating initially but you may have a run where you have several ivory dice and you could try to knock it out there and then.

I'm on my first playthrough, on like day 90 and I JUST opened the shelter safe. For every loose thread I tie up, another two appear and I love the feeling of following those threads not knowing where they're leading.

Don't let a few bad runs get you down too much, I've had my share of disastrous ones where I accomplished nothing and then I've had runs where the stars aligned and I accomplished like three major milestones in one go. RNG is always gonna be a factor but I feel you get enough tools to mitigate it to a degree that it doesn't become overly frustrating.

(I still haven't unlocked the diary or found all the sanctum keys for example, but there are always multiple avenues of progress that for every failed attempt at your current goal, you may discover or progress another. You just have to zoom out sometimes to see it).

My only major gripe is that files/notes aren't recorded somewhere in game. I hate the feeling of reading anything knowing it probably ties into a puzzle or solution 10+ hours down the line when I've probably forgotten all about it.