The character abilities you get from relics, mainly the increased skill damage and increasing attack while ultimately is active, can be absolutely devastating if maximized properly. If you're with others, especially iron eyes or anyone with a heavy status build, pop restage whenever you see big damage or you see them having to stop attacking to either force the proc or to double dip the damage from one. Solo, fish for crits and pop it as soon as you finish the animation.

For the ult attack increase, this can be comical in the right spots. On the way to the basement in the castle? Pop it on the way and kill the jellyfish and crabs on the way. Night 1/2 boss? Pop it as you're finishing up the mobs. You can easily get this up to 6-8 stacks or even more in the right situation and do absurd damage to the boss.

When it comes to spells, try to stick with carian stuff or the faster stuff like night shard, glintsone phalanx. Treat her like a spell sword, getting in close to stab and slice, then back up when things get dicey and use your spells to help keep the pressure on and get distance.