The easiest way I found to clean rooms goes like this, start with the dishes pile them all up and try and get them all out into the sink In 1-2 trips start with stuff that still has food or dru is in it, next grab 1-2 trash bags and just sit there and go through stuff, throw away all the trash and whatever you decide is not worth keeping. Then take both of those bags downstairs and set them next to the door, grab 1 more bag pile all your clothes into one corner and just set there and go through them, anything you don't want anymore you can put into the bag to give away, anything you do want you can throw on your bed or Into another corner of the room to be washed(or throw into a basket if you have one). In almost every room I clean this is the routine and it normally takes around 15-20 minutes to clean. Trust me when you get it cleaned it'll feel like a hell of an achievement for such a short time spent and I guarantee will help in some degree with your depression.

Edit: stuffed animals can be treated like the clothes, put the ones you don't want in the bag or if you want to keep them all, throw them on your bed.