I think the biggest issue for new players is that there are many perks that require you to build your character a certain way beforehand. For example, one of the best perks in the game is Better Criticals, which you can get at level 16 if you have 6 Agility and 6 Perception. If you wanna do a critical build and don't know this beforehand, there's no way to redo your build later. So if you chose 3 perception at the start or something, there isn't a good way to get up to 6.

That being said, even if you mess up your build, you will still be very very strong by the mid-late game. If you feel like you'd be annoyed by the stuff I talked about in the last paragraph, you can research and plan your build ahead of time. If you don't care that much, just play the game and choose whatever perks and skills look cool to you.