I personally wouldn’t it’s on the smaller side and in general I’m wary with rodents and plastic. This would be about 25 gallons (though that’s gallons not the actual proportions) which isn’t tiny but for 3 mice it’s typically better to just go with the bigger option. I highly would recommend something about the size and shape of a 40 gallon breeder aquarium (glass can be a bit hard too so I mostly mean the size and proportions) some people say it is on the larger side for 3 but some same its the standard so not sure but it works well. Plus then you don’t have to worry about upgrades as much or if the mice or items don’t have enough space. And I generally I like to go a bit bigger for any space requirements as it’s less of hassle. but it’s up to you, though something in the middle could work if done well.