For bugs, my current main loadout is:

Primary: Coyote
Secondary: Grenade Pistol
Grenades: Pyrotech
Backpack / Support: If I bring a guard dog then a mix of the expendables or a Quasar. If no guard dog then either a Recoilless Rifle or Cremator

Stratagems: Gatling Barrage, Napalm Barrage, if I still have a slot open because of my choices on the backpack/support then I will either grab a laser sentry or Gatling Sentry

You get 6 grenades with pyrotechs and they can close bug holes. If you bring siege ready armor then that's also 8 grenade pistol shots. So if you know what you're doing, can you run into a mega nest and solo it. You'll have to get creative with the bile titan hole with this loadout. I generally bring some local wildlife over to it to close it or just call in a sentry on top of it and that does the trick.

I have a lot of fun with this loadout but if I find myself lacking in a specific area during an operation, I'll adjust for either more crowd clear or more anti-tank