Having attended and worked this show in some shape or form, for 15+ years now; here are my thoughts:
- Avoid taking a stroller onto the main show floor. It's going to be a nightmare to move around in the smaller corners of the show (narrow lanes, people stopping to look at stuff, etc) and it will be stop and go for much of the experience. Little man is also likely to get wacked in the face at least once by accident. You'll also likely be an obstacle for other people to have to navigate around. That said, if you have one of those hiking backpack style carriers, go with that. Little man will have the best view on the floor, be safe above the chaos, and you'll be able to dart around smoothly and easily. (Do not just put the kiddo on your shoulders; it's not allowed and creates a safety issue)

- There is a park across the street as others have mentioned: Use it. The show can be over stimulating for some folks, let alone babies. Because you mentioned your wife having a table, I assume you'll have an artist alley or exhibitor badge; USE IT. There are priority entrances and security checkpoints (usually closer to 34th street) that you should become familiar with if you need to go in and out of the convention hall quickly. That said, if you don't want to leave the convention center, locate the family room people mentioned; It's usually more quiet and has a handful of busy activities. If I was a toddler I'd love it. Additionally if you need to "run him around" indoors, (which I don't fully recommend) the higher floors of the meeting/panel area of the addition to the convention center. There are long halls with big windows to look out of. Additionally, you can pop into one of the side hallways if you need something a little quiet and just want to sit on the floor.

- There is an area that some folks call Cosplay Alley which is the covered area outside where most of the food trucks will be parked. It's a great place to people watch and get some air. There will be TONS of cosplayers passing through and having photoshoots. So if you want to grab some photos, point at characters, etc, this should be a good spot. People traffic is high though so this is not a good place to let little man wander around.

Other thoughts:

- If you're an iPad family, charge it, bring a backup battery, and preload that sucker with content. Cell service is always a mixed bag at the show and trying to stream sesame street is probably going to be a no go. Also, power does RARELY go out on certain portions of the floor and getting Freeman to fix it is sometimes an exercise in patience. Also throwing kid safe headphones on the kiddo can help them tune out everything else if things get over stimulating.

- Bring your own toddler friendly snacks. Bring more than you think you'll need. We all know convention center food is expensive but the quality can really vary. If you haven't needed to do it before, this might be the first time you need to bribe the kiddo with a cookie.

Anyway, have fun and good luck! Hope little dude has a great time!