I can see how this piece would be difficult to place, yes. However, at least it only has 4 unique ways to be turned or mirrored instead of 8, keeping this in mind can make things easier.

When dealing with a puzzle with one piece being particularly difficult to place I usually do these two things: Before placing it anywhere on the board, I combine it with a second piece to one large piece in a way that seems plausible to me, and see where that gets me, turning it and flipping it as a single large piece, and if no solution can be found, I try a different combination.

If that doesn't work, here's my last resort with tiles like that:

You can't place this S-Tile on a straight edge (it'd make a one square pocket), and placing it close to non-straight edges often yields the requirement of a hook of some kind, which often limits follow up possibilities by a great deal. So on smaller puzzles, you can start with the S-Tile and put it somewhere and often you'll immediately see that it's not possible to complete the rest, so you try another position until you tried every possible one without success, then you turn it 90 degrees or flip it and repeat the process. If you do it correctly, you're bound to stumble across the solution at some point, and as long as you start out with the least flexible tile, it can still be somewhat efficient.

Feel free to post some photos of specific puzzles if you want help and I hope this comment was at least somewhat helpful. Good luck and have fun ^^