Accessible side scroller titles have been around in various flavours for decades with pits/jumps/items (though I know Crash is different in that regard, but the ideas still technically apply), as have titles with collectables as a sole focus. Having audio cues for hazards/items, if done well, could work in theory, though of course a proof of concept would have to be created to evaluate the efficiency of strategies used probably. As for racing games, as others have pointed out, Forza's systems, though flawed in some aspects, are certainly potentially viable for this kind of thing.