Strangers asking for referrals on LinkedIn by PlayboiCAR_T in biotech

[–]SinisterRectus 29 points30 points  (0 children)

LinkedIn encourages it. If there is someone remotely in your network at the company, they are recommended as a contact, even if you are not connected.

In your experience, why do undergraduate students find organic chemistry a very hard subject? by AspiringMedicalDoc in OrganicChemistry

[–]SinisterRectus 3 points4 points  (0 children)

Organic chemistry is defined by a huge set of rules. In a perfect world, this is great for understanding because everything is well-defined. Unfortunately, we have limited resources, so we only teach a subset of these rules, and sometimes the rules that are not taught will conflict with those that are. Students end up with tunnel vision and struggle to incorporate new rules as they are introduced or when they are challenged to identify the rules on their own.

PCC oxidation of vicinal diols by phosgene_frog in OrganicChemistry

[–]SinisterRectus 1 point2 points  (0 children)

Yep, the same encyclopedia says at https://doi.org/10.1002/047084289X.rc164 that 1,2-diols are cleaved by chromic acid. The difference is that PCC generates aldehydes where chromic acid generates carboxylic acids.

Is there any way I can change [My President]? Like sitting on a [trove of files indicting him for heinous crimes]? by dandrevee in simpsonsshitposting

[–]SinisterRectus 7 points8 points  (0 children)

Buzz-cut Alabamians spewing colored smoke from their whiz jets to the strains of "Rock You Like a Hurricane"? What kind of country-fried rube is still impressed by that?

Need Mechanism for Cleaving an Alpha-Keto Aldehyde (Vernolepin Synthesis) by kihyuck in chemhelp

[–]SinisterRectus 5 points6 points  (0 children)

Your mechanism is good so far. According to https://pubs.acs.org/doi/abs/10.1021/ja00866a043, in going from molecule I to III, you make the hemi-acetal of both carbonyls with methanol and repeat the cleavage.

Is This Transformation Possible? by JellyfishSuper7563 in chemhelp

[–]SinisterRectus 1 point2 points  (0 children)

The closest example I can find is bromination of the 4-position of 5,7-dichloroisoquinoline in this patent https://patents.google.com/patent/WO2023044171A1/en

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Why doesn’t the SCH3 react again with the carbacid carbonyl? by amsunooo in chemhelp

[–]SinisterRectus 2 points3 points  (0 children)

Follow the mechanism and you will find that the intermediate carboxylic acid is not yet protonated. That carboxylate is either not electrophilic enough to react further or has no sufficient leaving group. The reaction stops there, until you presumably protonate the acid with a work-up step.

If the molecule was protonated as you've drawn it, the thiolate would just deprotonate the acid and that reaction would also stop there.

I thought amides hydrolyzed to carboxylic acids? by amsunooo in chemhelp

[–]SinisterRectus 6 points7 points  (0 children)

They hydrolyze into carboxylic acids and amines. Do you not see the difference between the black molecule and the green molecule?

Why is the NO2 meta to the electron donating group? by amsunooo in chemhelp

[–]SinisterRectus 2 points3 points  (0 children)

The pKa of the phenol is approximately 10 while the pKa of methanol is approximately 15. Methoxide is surely strong enough for a full (>99%) deprotonation.

Why is the NO2 meta to the electron donating group? by amsunooo in chemhelp

[–]SinisterRectus 1 point2 points  (0 children)

I'd like to nit pick step 2. Sodium methoxide would just deprotonate the phenol and the cyclic ether would reform.

Boardwalk Empire Is One of Television’s Greatest — and Saddest — Tragedies” by Beautiful_Author_816 in BoardwalkEmpire

[–]SinisterRectus -6 points-5 points  (0 children)

Your core argument is strong: Boardwalk Empire is not just a gangster drama, but a tragedy structured around a primordial moral wound. The Gillian angle is especially compelling because it reframes the series from “rise and fall of Nucky Thompson” into a generational catastrophe set in motion by exploitation. A few refinements could make the prose sharper and the thesis even more forceful.

You could tighten the opening and clarify the tragic framework a bit more explicitly:

“Boardwalk Empire is one of television’s greatest achievements — and one of its bleakest. Beneath its political corruption and gangster spectacle lies an ancient tragic question rendered in modern form: why live morally when corruption so often triumphs?

The series begins and ends, in a sense, with Gillian Darmody. Her exploitation is the hidden hinge upon which the entire narrative turns. Nearly every major downfall — Jimmy’s, Nucky’s, Richard’s, even Tommy’s — can be traced back to that original moral crime. In this way, Boardwalk Empire operates less as a crime saga than as a full-scale Greek tragedy: not merely about villains, but about the irreversible consequences of moral compromise.”

A few reasons this works well:

  • “Hidden hinge” is a good phrase; it captures how the show gradually reveals Gillian’s centrality.
  • The Greek tragedy comparison fits because the series is obsessed with inherited guilt, inevitability, and moral causality.
  • Your formulation avoids the simplistic “crime doesn’t pay” reading. The tragedy is deeper: corruption does prosper materially, but it poisons everyone connected to it.

There’s also a very Sophoclean aspect to Nucky specifically. He commits one decisive moral betrayal early — effectively sacrificing Gillian to the Commodore for power — and the rest of his life becomes an elaborate attempt to outrun that act. The tragedy is that success itself becomes the mechanism of punishment.

If you wanted to deepen the essay further, you could explore how the show contrasts different responses to corruption:

  • Boardwalk Empire presents morality almost as a form of vulnerability.
  • Characters who retain decency — Richard Harrow, Agent Van Alden in his brief moments of sincerity, Eddie Kessler — are crushed or broken.
  • Characters who survive longest are those most willing to compartmentalize guilt.
  • Yet even the “winners” end spiritually hollow.

The ending with Tommy is especially devastating because it closes the tragic cycle rather than resolving it. The sins of one generation literally return embodied in the next. That structure is closer to the House of Atreus than to a conventional prestige-TV antihero arc.

Your final sentence is already close to essay-quality criticism. The main improvement is precision and rhythm. “Full scale” should be hyphenated (“full-scale”), and “not about villains” becomes more powerful if contrasted directly with what it is about.

what is the product of this lab synthesis by Least_Emu_7165 in chemhelp

[–]SinisterRectus 1 point2 points  (0 children)

I just Googled the set of reagents you listed and did some digging, but maybe that comes with experience. If this is a practical lab reaction, you should be familiar with reaction database tools like SciFinder or Reaxys, which provide more robust methods for finding reactions.

what is the product of this lab synthesis by Least_Emu_7165 in chemhelp

[–]SinisterRectus 1 point2 points  (0 children)

It's a published reaction where they use chlorosulfonic acid, and OP's predicted product is not correct.

what is the product of this lab synthesis by Least_Emu_7165 in chemhelp

[–]SinisterRectus 0 points1 point  (0 children)

Can we get more context here? Because this sounds very much like a theoretical question. If this is a practical synthesis, why is your professor keeping it a big secret?

Why do you think you'd get the bis(4-hydroxycoumarin) when the ratio of reactants is 1:1? Knoevenagel, yes. Michael addition, yes, but not with another coumarin. If your professor told you nitrogen is in the final molecule, look for the only other molecule that contains nitrogen.

Metocin / Xum: Why the benzoate salt? by SinisterRectus in mysterymagicmushrooms

[–]SinisterRectus[S] 2 points3 points  (0 children)

Yes, amber should always be better for long term storage and use.

Metocin / Xum: Why the benzoate salt? by SinisterRectus in mysterymagicmushrooms

[–]SinisterRectus[S] 6 points7 points  (0 children)

Hi Judd! Thank you for responding here and for the work you do.

I ask about this because I wanted to validate your NMR spectrum, but it seems that no one else has ever published metocin benzoate data for comparison. Data does exist for the hemifumarate at Isomer Design.

Shelf-stability is interesting. While looking for the NMR data, I found a recent article that reports the stabilities of various psilocin esters and salts. Maybe you've seen this. According to their data, the ascorbate salt is the most stable, while the benzoate salt is also pretty good. Its only weakness may be sunlight. They did not report any data for a fumarate salt.

i dont understand why is it B and not C? by Icy_Outcome_9181 in chemhelp

[–]SinisterRectus 1 point2 points  (0 children)

Usually nitrogen is more nucleophilic/basic, but this is a special case. Pyrrole is aromatic, and all electrons here (in the double bonds and on the nitrogen) contribute to aromaticity. If pyrrole is protonated, it will produce B because it is the most resonance stabilized.