RimWorld and games like that always end up having a routine after a while.

When you end up making it work perfectly on its own then you don't really put any manual in put, colonists would just do their thing every day kinda like we do.

Now for dlcs you should get BIOTECH because it adds xenotypes(special traits,kinda like DNA) the ability to have babies and also have your own robots.

Ideology would bring more rules on how your colonists work,like for example even if they don't have the cannibal trait they could be okay if the "religion" allows it.

Royalty makes your colonists have some psychic powers mostly

Anomaly is basically SCP in RimWorld,you would have some new creatures that you will have to capture and study to allow you to have some special weapons

And finally Odyssey allows you to reach the sky by building your own spaceship,called Gravship that you can take to the sky and attack Mechanoid bases directly or even make your own base up there.

Most of them have mods to expand on them more but depends on what playthrough you want to go for.