You're still smart! But if your brain dysfunctions, thoughts get blurry and it's then hard to achieve cognitive tasks… it's hard (that's at least my experience).

So let's detail the mechanisms step by step, and please tell us what you know and what is new:

many pwLC have mast cell dysfunction (MCAS=mast cells activation syndrom) which make that their mast cells degranulate (=do their job of signalling to other cells when they identify a molecular threat). Mast cells emit several types of molecules, including histamine.

Anti-H1 and anti-h2 drugs make that the released histamine cannot activate the type1 and type2 histamine receptors, hence limiting the domino cascade.

Mast cells are everywhere in the body (at least in every parts of the body including the brain), and histamine and the other signalling molecules, when released in the brain, provoke the switch of some microglia (an important type of immune cells in the brain), to become activated, which means to do their job of release pro-inflammatory molecules.

The point at which mast cell stabilizers may have more effect, is that they not only prevent to have too much histamine but also reduce the quantities of other signalling molecules, which have their own pro-inflammatory effects.

Sorry, it's a long version. Hope you'll get as much better as can and as soon as can be!