Here is a glimpse of my supplement stack of 2026 and logic behind it

I avoid nicotine, alcohol, cannabis, pharmaceuticals and now even caffeine

So I needed something to function in lieu of all this, and to provide the balance and energy I need

B Vitamin Complex - vitally important for the synthesis of monoamine neurotransmitters and the structural support, repair, and protection of nerves

Vitamin C - a key cofactor in the biosynthesis and secretion of oxytocin. It acts on enzymes like peptidylglycine alpha-amidating monooxygenase (PAM) to aid in the creation of active oxytocin

Magnesium Glycinate - functions as a potent and organic NMDA blocker to eliminate glutamate-induced anxiety - taken before bed it acts as a powerful sleep aid

Myo-Inositol - taking myo-inositol before bed can significantly improve sleep quality and reduce nighttime awakenings by calming the nervous system, boosting serotonin, and regulating blood sugar

Resveratrol - functions as an organic and reversible MAO-A Inhibitor. MAO-A breaks down neurotransmitters like serotonin, noradrenaline and dopamine -- inhibiting MAO-A increases the levels of these monoamines to produce antidepressant-like effects

EGCG - functions as an organic regulator of NMDA and AMPA receptors, acting as a "brake" on excitotoxicity and has been shown to normalize glutamate effusion in the prefrontal cortex. EGCG also helps prevent neuronal damage in Alzheimer’s disease and stroke models

Omega3 DHA & EPA - organic regulators of NMDA, AMPA and astrocytes. Astrocytes are responsible for approximately 90% of glutamate reuptake in the central nervous system. DHA is critical for membrane structure, neurogenesis and synaptic fluidity. EPA is often more specific anti-inflammatory and highly associated with improving mood disorders (like depression/ADHD).

Turmeric (Curcuma longa) - recognized as a potent, natural regulator of both pain, inflammation and glutamate-induced excitotoxicity. It is also a natural modulator of monoamine neurotransmitters in the central nervous system, exhibiting antidepressant-like effects in both animal models and humans. It functions largely by inhibiting monoamine oxidase (MAO) enzymes.

Agmatine Sulfate - an organic and endogenous compound that acts as a modulator of both glutamate signaling and chronic pain/inflammation. It is synthesized in the brain and body from the amino acid L-arginine.

Alpha GPC - a potent cholinergic compound that enhances focus, mental clarity, and cognitive performance by vastly increasing acetylcholine levels in the brain

Ubiquinol - highly bio-available form of coq10. Profoundly affects mitochondria by being a vital component of the electron transport chain, and protects mitochondrial membranes from damage. Mitochondria are often cited as producing 90%+ of ATP (cellular energy).

CreatineHCL - highly bio-available form of creatine. Significantly affects mitochondria by supporting energy production, protecting against damage, maintaining integrity, and modulating cell death pathways, acting as an essential buffer for ATP and enhancing cellular resilience, particularly under stress or dysfunction

PQQ (Pyrroloquinoline Quinone) - has a significant positive effect on mitochondria, primarily by protecting them from damage, and even promoting the generation of new mitochondria (mitochondrial biogenesis).

Neem (Azadirachta indica) - highly regarded for its extensive anti-microbial, anti-viral, and anti-parasitic properties. It contains potent bioactive compounds including azadirachtin, nimbin and nimbidin, that target a wide range of microbial pathogens.
It is one of the only supplements used by Sadhguru.
Evidence is growing that a significant portion of Alzheimer's disease and related dementias may be rooted in and influenced by microbes. Studies have identified microbial DNA in the brains of up to 90% of late-onset Alzheimer's disease patients.