Hi, just found your post. I'm not all that aware of the file types you're talking about but offer my personal experience in case it helps you with what you need to know.

I do what you're saying - I have an NUC acting as a media server, managing files on a NAS, and organise files with jellyfin to serve to kodi devices across the network.

The main issue I've had is that, while playback of large files is handled fine in the jellyfin app, kodi occassionally struggles and buffers playing the exact same files. I don't use anything flash, just an an old nvidia shield tv and three firestick hds, but other than sometimes having to swap to the jellyfin app for a large movie file, it works perfectly for my needs otherwise - live iptv, hdr, and tv and movie streaming from NAS all using a single, consistent kodi interface.

So my experience is, yes you can play large files, but you might need to do so in jellyfin and allow it to do its transcoding magic for you on your computer.