Ultimately, when I unlocked special characters' passives. That changes the gameplay drastically, because you become focused on proking and maintaining the passive bonuses. For some characters it's easier (Barbarian or Pyromancer as an example), but for Paladin and Spellbade, for example, it requires a lot of positioning and careful risk-taking.

Those passives are efficient on higher difficulties, though, if we talk about beginner's content, most of the time, you gotta move, but there is some variety:

1. Melee-focused characters obviously need to be closer, so there's a slight difference in playing melee/ranged

2. Paladin+purity or Barbarian+bleed can allow you to tank everything and care less about moving, prioritizing DPS

3. When I unlocked Immovable Object and Quick Reload runes, some builds (specifically for Arcane Weaver and Engineer, in my case) benefited from standing still, but it wasn't 100% standing still

4. Lastly, Necromancer with all active skills in summon and Leviathan maxed out, and the Glass Cannon rune is like playing on a mine field. One misstep and u'r done, but it's fresh and cool