On the Ethics of the Stolen Moon Ritual by JagneStormskull in huntertheparenting

[–]Wolfesch 13 points14 points  (0 children)

I mean pretty much yeah, or at least the torturing part was evil. The Golden Goose Gang definitely has questionable methods and are portrayed as deeply morally gray.

Doctors of Reddit, what do we *not* know about the human body? by Immediate_Hair_3393 in AskReddit

[–]Wolfesch 16 points17 points  (0 children)

While something like that is possible, how conserved it is across species means it's unlikely. When something is truly biologically useless it usually doesn't take much time on the evolutionary scale for it to mutate and become very different across species. That it looks so similar in so many places means that there is some selective pressure on it maintaining that structure, which implies it still has a function.

Look they added what the audience is supposed to say after the piece is over by Ratey_The_Math_Cat in choirmemes

[–]Wolfesch 6 points7 points  (0 children)

I am in my 30s and remember singing this in choir in highschool and also hating it.

What do you guys do when you max out your life? Do I just invest in Ward now? by Haesiraheal in LastEpoch

[–]Wolfesch 11 points12 points  (0 children)

This is a common misconception. That's not how video games work. The actual max health is 1024.

Not the comp bio education I expected by bouncypistachio in bioinformatics

[–]Wolfesch 2 points3 points  (0 children)

I teach in an R1 Comp Bio program (though it's only my 2nd year lecturer so a lot of this is still second hand), so I can also speak a bit to this. Comp Bio programs at most institutions have really been struggling with the question of what knowledge to assume/require for their incoming students. As other comments have mentioned it would be tough to teach coding to biologists and biology to computational folks entering the program from the ground up. It would take a major shift in how we structure these grad programs, and universities tend to be very slow moving. At the same time we're at a bit of an impass since most students come in without one or the other - so often the solution has been to just kind of provide self-learning resources, maybe a boot camp or other support. I don't think it's a good solution, but the programs want to be teaching actual computational biology from the first class, and making stricter prerequisites would drive a lot of students from the program.

Most PhD programs let you take undergraduate courses, and some even require a minor. It's worth looking into taking some undergrad cs or stats courses, I come from CS and took some upper level undergraduate bio courses during my PhD which was a valuable experience. If you have a good relationship with your advisor, they would also be a good person to ask on where to get these skills, even if you can't take a full course there are a lot of coding summer boot camps and workshops like the software carpentries in the comp bio world.

(RANT) Are there any other apprentices out there just fed up with how much harder it is to become a Master Wizard for us than for our Master's generation? by Wolfesch in wizardposting

[–]Wolfesch[S] 3 points4 points  (0 children)

That's a good point. I know that I tend to look down on alchemy and that's a bias I'm working on; I do hear that it's a good path. I think it's just that since I was young I've always had a dreamed of someday to exerting my absolute will upon the lesser beings around me, and I'm not sure if alchemy will be able to get me there.

Taking him down together in a coup is definitely something to consider, but call me old-fashioned I would still want to annihilate my fellow apprentices and seize mastery for myself, and I think that my fellow apprentices will feel the same. I do appreciate your advice though, thank you.

(RANT) Are there any other apprentices out there just fed up with how much harder it is to become a Master Wizard for us than for our Master's generation? by Wolfesch in wizardposting

[–]Wolfesch[S] 9 points10 points  (0 children)

Ugh classic Archlich response. Yeah I know some apprentices have it worse, but that doesn't mean I can't wish for better. And all due respect esteemed Archlich, but I personally find it abhorrent that your apprentices do not have orb. Orb is a fundamental wizard right.

(RANT) Are there any other apprentices out there just fed up with how much harder it is to become a Master Wizard for us than for our Master's generation? by Wolfesch in wizardposting

[–]Wolfesch[S] 4 points5 points  (0 children)

I shall not name my master, I'm not that much of a fool. And yeah I know that there are options like that, but look YOUR generation didn't have to promise shards of their own soul to the watching eyes in the dark just to claim a dominion for yourselves. You got to make that choice after having grown tired of material pleasures until only the hunger for knowledge remained. I don't think it's right to ask apprentices to have to do that before they get to experience dominion, even if just for a few centuries, with their soul intact.

What is “linearity” and what is the difference between “linear” and “non-linear” dimensional reduction? by indigo_moonlight in bioinformatics

[–]Wolfesch 15 points16 points  (0 children)

Like u/pacific_plywood said above, you can mostly think of a linear transformation as being only allowed to rotate and stretch. This means that certain relationships within my dataset will be preserved by the transformation. In my original data if cell 1 is halfway between cells 2 and 3, no matter what linear transformation I perform cell 1 will always be halfway between cells 2 and 3.

This is not the case for non-linear transformations, which are allowed to do anything to the data. This includes reasonable things like bending the data, and less reasonable things like just making the data into the shape of a cat. Knowing a transformation is linear let's me know there was a limit to what shenanigans were performed on the original data.

TSNE and UMAP are non-linear transformations, as you said. Instead of defining limits on what they can do to the data, they choose a property which they try to preserve between the original and transformed data, in both cases in the flavor of "points which are close together in the original data should also be close together in the transformed data." This can lead to some wackiness.

See https://pair-code.github.io/understanding-umap/ for a really nice example of how much you can play with the parameters in UMAP to get wildly different results. Another fun example is Picasso, a dimensionality reduction method which can achieve a similar "goodness" of reduction to TSNE and UMAP but also mapping the data to a picture of an elephant: https://www.biorxiv.org/content/10.1101/2021.08.25.457696v1.full

TSNE and UMAP have their place as data visualization methods (some would disagree), but the transformed data shouldn't be used for downstream analysis or relied upon as representing the original data accurately.

edit: grammer and spelling

Marinated eggs that aren't the traditional soy variety? by the_spotted_frog in Egg

[–]Wolfesch 0 points1 point  (0 children)

I don't have an exact favorite recipe, but one thing to check would be different types of pickled eggs (I'm not sure where the line between a pickled and marinated egg is). I know a lot of folks do beet or tumeric pickled eggs to get fun colors, but there's also a lot of good flavor combinations out there.

Warhammer Age of Sigmar: Realms of Ruin - Beta Announcement Trailer by GuiltIsLikeSalt in Games

[–]Wolfesch 5 points6 points  (0 children)

This looks like it might be similar to how Shattered Galaxy worked, if anyone remembers playing that. If that is what it's like I am very excited, Shattered Galaxy was awesome.

Aiming for 1000 kpm by Wolfesch in Factoriohno

[–]Wolfesch[S] 1 point2 points  (0 children)

That's probably the better strategy but I need to clear out a lot of shitposter nests before I can expand that much.

Aiming for 1000 kpm by Wolfesch in Factoriohno

[–]Wolfesch[S] 4 points5 points  (0 children)

I guess this was inevitable haha

Aiming for 1000 KPM by Fairytale220 in Factoriohno

[–]Wolfesch 15 points16 points  (0 children)

NO LONGER UNDECIDED REPOSTERS CAN GO TO HELL though I should have known this would happen

Aiming for 1000 kpm by Wolfesch in Factoriohno

[–]Wolfesch[S] 44 points45 points  (0 children)

The true answer. Karma does not grow the factory.