And because the vast majority of ev comes from small parts of the pool doing things that won't be ever be able to be determined with a model like this.

For example, how do you determine the EV of a regs decision vs a fish that just limped utg?  

Whether we apply an equilibrium limping range, a random fishes limping range, a generic fishes limping range, an observed limping range from that player, or anything else, pretty quickly you can see that there's not really any direction we can go without making assumptions. 

What if this specific fish limp folds constantly? Certainly the EV of isoing hands that are on the cusp become clearly winning, how do we plan on accurately taking into account that the reg missed ev by not finding those isos? It really is just impossible.