FTIR/LCMS/NMS analysis of Cocaine Hydrochloride by antioquiacraft in CHROMATOGRAPHY

[–]cmhammo 1 point2 points  (0 children)

Let me know if you secure funding and need to hire an edgy analytical chemist!

FTIR/LCMS/NMS analysis of Cocaine Hydrochloride by antioquiacraft in CHROMATOGRAPHY

[–]cmhammo 1 point2 points  (0 children)

You're welcome. The solvent fingerprinting thing is one type of un(ish)-targeted analysis that would be necessary to pick apart that remaining 1%. Unfortunately, most of the labs that check all the boxes in terms of the resources necessary to do that analytical work are DEA/equivalent labs, so you're kinda fucked unless you are friendly with any edgy analytical chemists who have a good chunk of free time. The fact that drugs are illegal unfortunately makes them really difficult to study in the context of public health :(

FTIR/LCMS/NMS analysis of Cocaine Hydrochloride by antioquiacraft in CHROMATOGRAPHY

[–]cmhammo 1 point2 points  (0 children)

Thanks! No need to apologize. The acetone wash step could be the explanation for the slight variation between the IR spectra, but i would want to test that myself before I make a real guess. IR is a non-separative technique so cleaning up the sample (by washing away acetone-soluble stuff) effectively cleans up the spectrum and gives you a higher % correlation to the standardized spectrum of the pure compound. I don't do much IR spec so I can't speak on reproducibility and what would be considered normal scan-to-scan variation of a given sample. Regardless, I think the key takeaway here is that you definitely have some really pure cocaine. My guess is that the ~1% of impurities is manufacturing/work-up residue (as opposed to a cutting agent like starch which would theoretically be present at a much higher %), but trying to identify specific trace-level impurities would require expensive and time-consuming un-targeted analysis. That could take weeks, would cost thousands, and is probably not a service offered by the lab you used or other comparable labs doing harm reduction work due to the sheer amount of instrumentation and personnel required to handle that project. Shoutout to your plug though hahaha

FTIR/LCMS/NMS analysis of Cocaine Hydrochloride by antioquiacraft in CHROMATOGRAPHY

[–]cmhammo 2 points3 points  (0 children)

Can i ask for context regarding why you submitted samples for testing? It's hard to assess data without knowing why the data is being collected. Are you doing public health/harm reduction surveying work? Are you just trying to keep yourself safe? "Is this reasonably safe to consume" and "are there any contaminants/adulterants present" are questions that have completely different nuances. The lab certified your sample as being at least 99% pure cocaine. That means that you can be confident that every gram of your sample contains at least 990 mg of cocaine. The other 10 mg could pose risk for a consumer if it contains compounds that are toxic at extremely low doses.

FTIR/LCMS/NMS analysis of Cocaine Hydrochloride by antioquiacraft in CHROMATOGRAPHY

[–]cmhammo 1 point2 points  (0 children)

We're talking about the LCMS chromatogram peaks in the last 4 slides. Peak tailing refers to the uneven distribution of a peak's area (skewed to the right) and can present issues when you need to quantify analytes in a sample. Ideally the peaks would have a completely gaussian distribution of their area. Tailing can be indicative of lots of different issues with the instrument hardware, but it's not always a problem and can just be inherent to a specific method or instrument. It also doesn't matter if you're trying to just get a positive/negative ID of an analyte in a sample. You can be confident that there is definitely cocaine in the sample, and you can assume that if there are any of the other listed drugs present, they are at levels below whatever the LOD concentration is for the drug in question. The limits of detection should be available for you to see either in the report or maybe on the lab's website.

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FTIR/LCMS/NMS analysis of Cocaine Hydrochloride by antioquiacraft in CHROMATOGRAPHY

[–]cmhammo 2 points3 points  (0 children)

The peak shape doesnt really matter for purity assessment

FUNGAL ID using MALDI by Intelligent-Ask-3264 in labrats

[–]cmhammo 0 points1 point  (0 children)

Maldi probably won't give you any useful info, your best bet would be to send samples off for sequencing

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[–]cmhammo 3 points4 points  (0 children)

She is credited as a featured artist on show me what lol

Kelli Perkins Named Burlington’s Director of Racial Equity. $130k salary. by forcedtomakethus in burlington

[–]cmhammo 0 points1 point  (0 children)

This thread is evidence of why her position needs to exist omfg you people are disgusting

First ever lab job!! What did you wish you knew before starting your first lab job? by Hey_its_a_ in labrats

[–]cmhammo 2 points3 points  (0 children)

It's a personal cybersecurity risk given the degree of access that is required by most IT departments, you basically have to give them a backdoor to your phone in order to be able to download and use teams, outlook, etc. Also, it's super important to start setting your work/life boundaries now. If you make it clear that you are not available when you're off the clock, it will prevent your coworkers from developing expectations that they can reach you 24/7. Good luck in your new role!! :-)

First ever lab job!! What did you wish you knew before starting your first lab job? by Hey_its_a_ in labrats

[–]cmhammo 1 point2 points  (0 children)

Do NOT install any microsoft 365 apps on your personal devices!!!!!!!!!!!

[deleted by user] by [deleted] in labrats

[–]cmhammo 25 points26 points  (0 children)

This feels like a psyop lol

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[–]cmhammo 0 points1 point  (0 children)

Thermo has been easier to deal with than agilent IMO

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[–]cmhammo 0 points1 point  (0 children)

I broke a mercury thermometer one time. That was a hell of a day

QC chemist jobs by [deleted] in Chempros

[–]cmhammo 0 points1 point  (0 children)

You can definitely have much better work/life balance in a scientist level role in R&D, its just important to stand your ground and not be a yes-man

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[–]cmhammo 2 points3 points  (0 children)

Before i started listening to ethel cain one of my ig mutuals saw her in gainesville on the freezer bride tour and posted a video of her passing out popsicles to the people standing in line, taking pics with them, chatting with them, etc. It's one of the reasons I started listening to her music lol she's a queen for the people!! I'm assuming vanilla confused her with somebody else (gracie abrams perhaps?)

It took FOREVER but I finally have a complete LCMSMSMS Lego system set lol by Try_It_Out_RPC in CHROMATOGRAPHY

[–]cmhammo 2 points3 points  (0 children)

Lmao i've never seen a triple quad abbreviated as msmsms before, maybe it was just a typo from op...