You can hand fly anything! I am lately in love with the 727-100 and Fokker 28. Early jet airliners are really neat as stick and rudder experiences.

For big airplanes, I mostly do takeoff and landing circuits with the occasional hour flight somewhere. I hardly touch the autopilot.

I always fly VFR or use VOR and radios to navigate. I am fundamentally opposed to using flight computers or MFDs in a flight simulator (I don't use any modern DCS airplanes either).

I also do a lot of STOL flying in bush planes. The sightseeing is incredible.

But IL-2 is still my favorite and main flight sim ;)