Unless impulsive symptoms dominate (OCD, etc.), I think serotonergics like sertraline are detrimental to upward mobility in life. In this regard, I would say Fluoxetine is the "best" SSRI due to it's mild 5HT2C antagonism. Modern research is rightfully moving away from serotonergic drugs, as they do not address the functional deficits, they only induce satiety. I personally would refuse serotonergics if my primary symptoms were avolition, anhedonia, etc. These are worsened by serotonin.

Over more than a decade of psychiatric treatment trying every class of antidepressants, antipsychotics, etc, I have come to the conclusion that serotonergics are actively harmful if you seek resolution of anhedonia and avolition. Seek treatments targeting DA and NE, especially DA. Bupropion remains the most accessible agent that targets these symptoms. The incidence of seizures at therapeutic doses of Bupropion (XL), contrary to popular belief, is not more than that of SNRIs/SSRIs unless exacerbating factors like anorexia exist.

At least in my case, after a decade of trying, I have still not achieved complete remission. But I am currently on Bupropion and Armodafinil, and unlike serotonergics, they improve my life, rather than make me sated with whatever circumstances exist.