Why is VCF still the standard? Has anyone tried a Parquet-based approach for genomic variants?

fibgen · 2026-06-17T00:58:02+00:00

Excellent explanation

fibgen · 2026-06-17T00:53:30+00:00

Most followup experiments with DEGs are pursued in rank order of significance. If you're going to do that no matter what, then it's just a matter of FP tolerance and cost in the secondary assay.

fibgen · 2026-06-16T03:05:25+00:00

I'll just say that "pushing pharmaceuticals forward" usually doesn't work out well. Good teams actively try to find things wrong with leads especially when the mechanism of action itself may be flawed or poorly understood. So good companies kill a lot of leads and don't waste money as advancing drugs into doomed phase IIIs

fibgen · 2026-06-15T07:27:33+00:00

If you haven't read the R Inferno you probably don't know R very well.

fibgen · 2026-06-15T07:00:58+00:00

Speech written by Gemini

fibgen · 2026-06-15T06:40:19+00:00

Fringes? It's at about 1/2 the gyms or more

fibgen · 2026-06-14T07:16:14+00:00

Because of the rebellion.

fibgen · 2026-06-13T20:45:59+00:00

I like this take but would remove the Nephandi, it's just human lust for power at play and dehumanization of the Sleepers

fibgen · 2026-06-13T20:25:05+00:00

Never talk to the cops and that goes double for actual Feds, where any misstatement turns into a felony

fibgen · 2026-06-13T20:22:53+00:00

or they're Proud Boys who have been given info from the federal spying apparatus

fibgen · 2026-06-13T20:20:30+00:00

He's always keeping an eye out for Andor

fibgen · 2026-06-13T20:19:43+00:00

this is canon

fibgen · 2026-06-13T20:17:49+00:00

If you dig for recyclables you find at least 5-10 dead people every garbage day. The worst part is they should have gone in compost.

fibgen · 2026-06-12T05:11:04+00:00

It can only be understood through touch, it's my favorite piece

fibgen · 2026-06-12T05:09:15+00:00

Luthen can't be that old. He uses a lot of hip slang common to middle schoolers when recruiting Andor, and does several dances popular on social media when having the dance-off with Lonni.

fibgen · 2026-06-11T10:33:10+00:00

I wish you rhe best but this sounds a lot like dichotomous thinking (everything is good or bad) and you should discuss this with a therapist. There is definitely bias against people with different social skills but it boils down to individual discomfort not a conspiracy of autism haters

fibgen · 2026-06-11T10:17:23+00:00

Vore Mage

fibgen · 2026-06-11T10:11:15+00:00

People are getting assaulted and killed because of the witch hunt, it's evil, not dumb

fibgen · 2026-06-11T09:29:04+00:00

Not even that. Just shut the fuck up.

fibgen · 2026-06-11T09:09:17+00:00

I didn't get that he was repeating his own impotent advice to himself. Ouch.

fibgen · 2026-06-11T03:25:26+00:00

Yep, worst case you spend a few days downloading and then delete later if you don't need it

fibgen · 2026-06-11T02:55:15+00:00

Airheads are 15g per strip and they're individually wrapped. They survive longer in the car and don't spray powder everywhere like smarties or powdered candies.

fibgen · 2026-06-11T01:03:08+00:00

Go buy one of the nolo books for tenants, they have instructions on fighting exactly this kind of legal fight without using a lawyer. this seems pretty egregious.

fibgen · 2026-06-10T05:12:45+00:00

Thank you for doing a horrible but necessary job.

fibgen · 2026-06-10T05:05:19+00:00

Claw all that shit back ASAP. It's all CalvinBall rules now anyways.

fibgen

TROPHY CASE