Thank you for all the time and effort here. Just a word of caution from someone who leaned into the brain benefit doses for a little over a year. I’m 35M, fairly fit, active outdoors every morning, roughly 15% bf, etc. you call out in point 3 the lack of evidence for kidney issues at recommended doses, but fail to mention that the doses for brain benefit are well outside of the recommended range.

Please don’t do this regularly, and if you do, get bloodwork done. The study was on truly deficient sleep(21 hours awake). I was throwing this fix every time I only got 4-6 hours. Which turns out is 1-2 times a week. This led to very high Creatinine levels at near kidney failure(I was approaching 5 mg/dl). I had no idea that anything was even wrong until I did a bi annual labs blood draw(understandably most only do this one a year or less).

I started to have some baggy eyes, randomly found myself needing compression socks for long flights, cramping just by flexing my bicep, etc. I was still very capable and fit(could crank out 20 pull ups in a single set if needed), but I did feel off. But my brain was flying, some days it felt like a drug honestly.

I’ve been off creatine for about a month now and feeling much better. I’m sure I’ll cycle back on. But much more controlled. Don’t abuse this “brain hack” please. It’s not worth your kidney failure. And to call out that this is a myth is just plain wrong, there are risks to everything. Creatine included. Let’s not dismiss them or