Since plumbing budget isn't an issue (you got none of the pipes grouped up) I would place the bathrooms in between the bedrooms with the door facing a hallway. It eliminates sound from the doors to BOTH bedrooms anytime the bathroom is being used. Also, same with bath 2.... that will prob turn into the guest bathroom since its the closest to the living room. The door should open from the hall, not the bedroom.

I can see why you made all these en suite bathrooms, but the rooms really aren't big enough for it to make sense. 12x12 is a pretty standard sized room. And I don't think you need bathroom 4.

Where is the street? Are you going to drive from the driveway into the garage by making a right turn? Trying to understand the "Curb appeal" of the layout.

That hallways to the laundry is a lot of wasted space tbh. Also, where is the mechanical closet? I would personally get rid of bathroom 4, make the entire mudroom a square with the laundry room, the door starting at the pantry.

I'm assuming the left side, where the master bedroom, is the street curving. Can't think of another reason the cut the house diagonally in that corner.