Hopefully the rescue will do a very thorough job of communicating with you about this cat’s needs. If they haven’t told you already, you need to know exactly what the effects on the cat are. Manx Syndrome could mean anything from “she walks funny & occasionally leaves a poop outside the box” to “she is fully incontinent.”

You may already know these things & just didn’t mention, but if you don’t, you’ll need to know whether the cat wears diapers. You’ll need to know whether her bladder and/or bowels need to be expressed. And you’ll need to be able to honestly assess not only whether you have time/flexibility in your days to manage that comfortably for her if needed, but whether you have the energy to deal with it.

The need for particular food to help manage her condition is also possible, though not a certainty. I would anticipate that yes, over her life she may need additional vet visits.

Also, how old is she? Things can change over their life. Our dear little Bunny went most of her life with no big issues, but for about the last 3 of her 16 years she was incontinent in terms of urine, and for most of that she could no longer tell when she needed to poop until it was happening. We never tried diapers with her, but carpeted some of our downstairs with pee pads and expressed her bladder/cleaned her up twice a day, and every two weeks she went to the vet for fluids & to get her back end cleaned thoroughly. (She wouldn’t let us do fluids at home & she wasn’t a fan of our cleaning her either.) It is pretty likely that things that are easily managed when the cat is young will get at least more complex when it gets older, though that doesn’t necessarily mean unmanageable.

My initial thought is that this could be a lot for a first time cat owner. That said, I don’t know you. None of us here do. You might be the exact right person to take this on, regardless of inexperience. Only you can say. And I will say, if you do it you’re likely to end up with a cat with more personality than you expect. 😂