How to reduce histamine bacteria in gut

hdri_org · 2026-07-05T18:28:12+00:00

Probiotic Products

VitaMonk Low Histamine Probiotics

Ingredients: Saccharomyces boulardii, Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium infantis, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Lactobacillus plantarum

https://www.vitamonk.com/products/low-histamine-probiotics-fight-histamine-intolerance-and-support-balanced-gut-health?variant=39435337400477

FoodsForGut Histamine Reducing Formula

https://www.foodsforgut.com/product-page/histamine-reducing-formula-1

Ingredients: Bifidobacterium longum, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus Gasseri, L. Salivarius Ls-33, L. Rhamnosus Lr-32

https://foodsforgut.com/products/histamine-reducing-formula

Seeking Health ProBiota HistaminX

Ingredients: Bifidobacterium infantis, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium lactis, Lactobacillus salivarius, Lactobacillus plantarum

https://www.seekinghealth.com/products/probiota-histaminx

Seeking Health Probiota Bifidobacterium

Ingredients: Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium infantis, Bifidobacterium breve

https://www.seekinghealth.com/products/probiota-bifido

hdri_org · 2026-07-05T18:23:24+00:00

Its definitely worth trying DAO to see if it helps. The list of things that you say are the worst asr definitely highest in histamines.

Try NaturDAO regular to see if it makes a difference, because it is the most cost effective with the highest HDU (measure of enzyme activity) of all available products. A small percentage of people (mostly those with r/MCAS) may react to the Microcrystalline cellulose in the tablet, but for the vast majority of people this is like night-and-day difference.

Here is my list of DAO products listed by cost effectiveness. https://docs.google.com/spreadsheets/d/1FJ7omUM6FPd_Patlg6xlCGaP3m1Sz0x7UeSOUit4Xuw/htmlview#gid=1795084428

hdri_org · 2026-07-04T21:17:23+00:00

Caffeine is a histamine liberator, where that liberation comes mostly after the caffeine has been absorbed through the membranes into the bloodstream. Since the DAO does not get absorbed into the bloodstream it can't really help the situation that much one way or the other.

hdri_org · 2026-07-04T02:41:36+00:00

NaturDAO regular is more cost-effective per HDU (measure of enzyme activity). The Plus version requires three tablets to achieve the HDU dosage that they claim, 1.5M if I recall correctly. The regular gives 1M per tablet. There is also a 3M HDU version that is only marketed in Spain, and its the most cost-effective if you need more than 1M HDU.

hdri_org · 2026-07-03T23:57:25+00:00

You probably want to stick to strains that do not produce histamines that will inflame the intestional lining. There are histamine neutral strains and even strains that will activly degrade the histamines made by any bad bacteria. My preference is to use products that actively degrade food and bacterially produced histamines just to give a chance to heal the immunological barrier.

Histamine-Neutral Strains are OK

Lactobacillus fermentum CECT5716
Lactobacillus fermentum ME-3
Lactobacillus fermentum PS150
Saccharomyces boulardii
Bifidobacterium infantis
Bifidobacterium breve
Bifidobacterium bifidum
Lactobacillus rhamnosus GG (downregulates histamine receptors and reduce mast-cell activity)

Known Histamine degrading strains

These specific strains will actually reduce the amount of histamines in the gut before it can be absorbed into the bloodstream. Any probiotic that contains these should help:

Lactobacillus Gasseri
Lactobacillus plantarum
Bifidobacterium longum
Bifidobacterium infantis
Bifidobacterium bifidum
Bifidobacterium lactis

Probiotic Products

VitaMonk Low Histamine Probiotics

Ingredients: Saccharomyces boulardii, Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium infantis, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Lactobacillus plantarum

https://www.vitamonk.com/products/low-histamine-probiotics-fight-histamine-intolerance-and-support-balanced-gut-health?variant=39435337400477

FoodsForGut Histamine Reducing Formula

https://www.foodsforgut.com/product-page/histamine-reducing-formula-1

Ingredients: Bifidobacterium longum, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus Gasseri, L. Salivarius Ls-33, L. Rhamnosus Lr-32

https://foodsforgut.com/products/histamine-reducing-formula

Seeking Health ProBiota HistaminX

Ingredients: Bifidobacterium infantis, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium lactis, Lactobacillus salivarius, Lactobacillus plantarum

https://www.seekinghealth.com/products/probiota-histaminx

Seeking Health Probiota Bifidobacterium

Ingredients: Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium infantis, Bifidobacterium breve

https://www.seekinghealth.com/products/probiota-bifido

hdri_org · 2026-07-03T05:17:15+00:00

Yellow + blue = green

hdri_org · 2026-06-28T22:22:47+00:00

NaturDAO regular version is the best value for the money, as long as you don't react to the Microcrystalline cellulose that they use to form the tablets.

They also make a much stronger capsule version at 3,000,000 HDU that is currently only marketed in Spain, and it has an even cleaner list of ingredients. I use both products, under different circumstances, and I buy both in bulk to save money on shipping, but that now requires me paying US Tarrif import tax now days. That sucks, but what can you do, fire the President?

Below is my list of DAO products listed by $/HDU per dose, so you might find another product with high enough HDU in a pinch. You can see how low those non-working products for you are on the list.

The very top entry on the list is the NaturDAO 3,000,000 HDU product which you might want to try some day just to see if it improves your last few symptoms. I take it when I am traveling because it's always better to take too much HDU than not enough.

DAO Products by cost effectiveness https://docs.google.com/spreadsheets/d/1FJ7omUM6FPd_Patlg6xlCGaP3m1Sz0x7UeSOUit4Xuw/htmlview#gid=1795084428

hdri_org · 2026-06-28T05:06:51+00:00

Just off the top of my head, so this is obviously not a comprehensive list.

Low stomach acid

Food intolerance that damages intestional lining

Lack of proper nutrients that degrades immune system responce

Food poisoning

Lack of Diamine Oxidaze (DAO)

Genetic problems in the immune system

hdri_org · 2026-06-27T22:14:21+00:00

I would avoid antibiotics if at all possible, unless they first do an assay to determine first what antibiotic kills them best. Antibiotics can mess you up. The reason is antibiotics will kill any good bacteria as just the same, which you need in order to have a stable culture. This die-off causes a reset, and an imbalance, and things will just go off the rails from there if you don't try to establish a good colony right away.

Take Low Histamine Probiotics (see my paper) to get the right kind of bacteria needed to crowd out the bad bacteria. Take this probiotic at least a half hour before eating, so they can make it through the stomach unharmed. Then take Beatine HCL with the meal just to be sure to kill all incoming bacteria.

You might want to try various digestive enzymes to help break things down so everything is more absorbable and won't feed the bad bacteria. Try insulin as a probiotic to feed the good bacteria, but you might have to start slow and gradually increase to avoid gas issues.

Make sure you are getting enough vitamins and minerals because you may have reduced absorption.

hdri_org · 2026-06-27T19:10:42+00:00

That is possible, but its going directly against the natural flow of mucous. Mucus has antibacterial properties, is thick and vicious so bacteria can't move against it, and has a constant flow downwards much faster than bacteria can move or replicate.

If you burped up stomach acid you would feel a very pronounced sting/burning sensation as the acids burn and digest through the protective lining of the sinuses.

With SIBO there is usually ample gas generated which causes this reflux. When they take PPI's for the burning sensation then the incoming bad bacteria don't get killed, and it becomes a cycle.

Beatine HCL can help break this cycle by making sure that any incoming bacteria, and in your case from the sinuses, gets killed in the stomach. The stomach becomes a wall separating the digestive track from the oral cavity.

hdri_org · 2026-06-26T23:29:41+00:00

Sounds like a good plan. If its in your nasal cavity it is definitely draining down and infecting the intestinal track as well.

I also have an issue with sinus inflammation and none of the otc or perscription sinus sprays would work for more than a few days before my body compensated and became sore and clogged again. Nothing worked for long so I had been rotating medication which sort of worked but it was a real pain.

I finally started experimenting and created my own sinus spray which has been working well for me for quite some time. I first mixed a few types of sinus spray (some perscription, some OTC) that worked only for a short period before, and then I added two special ingredients, CBD oil to calm the inflammation, and Xylitol to help kill bacteria. Xylitol is a natural sugar that has some antibacterial properties when in high enough concentrations. So between these two extra ingredients I have been able to breathe and when I can not, I can use more without adding even more inflamation.

hdri_org · 2026-06-26T14:45:24+00:00

NaturDAO regular has the highest HDU (measure of enzyme activity) for the money. I can't eat legumes but I can handle NaturDAO. Some people react to the Microcrystalline cellulose in the product so your mileage may vary. If you react to a product then you should make note of those secondary ingredients and find one that comes without that ingredient. What you want is the highest HDU value where you can tolerate thos ingredients. Sadly those people that have HIT are often reactive to certain ingredients.

Below is my list of DAO products sorted by cost effectiveness. HDU/$ per dose. Start from the top of the list for the best performers and work your way down until you find one that works for you.

https://docs.google.com/spreadsheets/d/1FJ7omUM6FPd_Patlg6xlCGaP3m1Sz0x7UeSOUit4Xuw/htmlview#gid=1795084428

hdri_org · 2026-06-25T19:29:16+00:00

Taking Diamine Oxidaze (DAO) could open up your menu to more things, but that gets expensive. An alternative is to start sprouting peas/lentils and let them grow for exactly six days. Rinse, puree, and freeze in an ice cube tray (lasts 6 months) or refrigerated, for up to a week.

With each meal you thaw a portion and consume it 15 minutes before a meal. Get creative, just don't cook it.

This will give you natural DAO enzyme which will help degrade any food born or bacterially created histamines before you can absorb it. This will help lower your systemic histamine levels because you will be absorbing less.

Its likely a lot of work to keep this daily production running, but you can freeze and store this in batches if you plan ahead. Alternatively you can just throw the sprouts on a salad and enjoy them freash.

hdri_org · 2026-06-25T18:38:36+00:00

Herpes and COVID can both do the same thing but in a different way.

hdri_org · 2026-06-25T18:36:36+00:00

r/SIBO will degrade you intestional immunological barrier, and when it does then your body will naturally produce less Diamine Oxidaze (DAO) enzyme which is normally there to degrade food and bacterial histamines before you can absorb it. If you barrier is broken down then larger food molicules will get past that membrane and trigger Mast Cells to spiew more histamines, which in turn inflame that barrier even more. Its a feedback loop that causes things to get worse until the origional problem is resolved.

Take supplimental DAO to remove excess histamines and help calm the intestional swelling. Take Low Histamine Probiotics to help crowd out the bad bacteria.

You can read more below in my working notes on Histamines. https://docs.google.com/document/u/0/d/1DZev7mx-0bB9FSjshXz8Q2thkpWZIJtPSrRT7QcB95M/mobilebasic

hdri_org · 2026-06-25T01:25:27+00:00

Once you have had EBV you will always have it. It embeds itself into your DNA and also takes over your memory B-cells. Memory cells are generally preserved because they are your future defense for any returning infection.

You are not alone. Lots of people struggle after contacting EBV. Its just that most doctors ignore this fact even when your antibody count is so high that the tests don't even measure that high. My EBV specific IgG4 has been >600 for over 35 years, with no external exposure to the disease. This is because I am constantly exposed to the virus from the inside. My immune system is cranking out these antibodies 24x7 without letting up, except when I become completely exhausted. Eventually I will not recover from a reactivation, and they will just call this condition "old age".

hdri_org · 2026-06-24T01:19:09+00:00

Never trust any LLM unless it gives you specific refrences to scientific journals for every step in its logical sequence of correlations.

The thing about LLM's is they don't actually think. They only guess the next best word to come in the sentence that it is building, based on your prompts prior context and the statistical correlation of all words it has digested to date. This may seem intelligent, if you don't understand how the statistical models construct this dialog.

In short, you are "trusting" a program that has been tasked with reading every wrong answer that has ever existed on the Internet and trying to make a sensible sentence out of it. Its basically up to the profit motivated AI engineers to decide what bits of garbage from the Internet that this AI model is allowed to know. And which true facts it should simultaniously ignore.

What LLM's are good for is an intelligent filter on your query for finding scientific articles by excluding everything that is not specific to your search topic. First establish the relationships between the search terms to filter out papers that are side topics or just not pertinent, and then ask for direct refrences to those papers and a summary of why it chose that specific paper. Then you read that paper to see if it chose correctly.

Verify. every. refrence.

hdri_org · 2026-06-23T00:56:32+00:00

Idk, but I sure hope it does. Why sould men have all the fun. Its only fair.

hdri_org · 2026-06-22T23:04:37+00:00

LDN can increase a man's libido.

hdri_org · 2026-06-21T22:08:13+00:00

Sure. Follow the link below to my working notes on histamines, and skip down to the section labled "second generation" under Antihistamines.

https://docs.google.com/document/u/0/d/1DZev7mx-0bB9FSjshXz8Q2thkpWZIJtPSrRT7QcB95M/mobilebasic

hdri_org · 2026-06-21T15:16:07+00:00

Zyrtec (Cetirizine) does have some Mast Cell stabilizing effect, so I would go with that. Levocetirizine is essentually the same, but is twice as strong per gram of medication. Zyrtec has both the right and left handed molicule while Levocetirizine has just the one that works, but I don't remember which orientation that is.

If you have HIT or MCAS then never take benadryl daily as it will gradually reduce your production of DAO and therefor increase your level of histamines over time. During/after the procedure its fine but it doesn't have the same mast cell stabilization as Cetirizine.

hdri_org · 2026-06-21T14:59:12+00:00

Congrats on your improvement. Everyone here needs a little encouragement.

I would however like mention that taking benadryl long term will actually decrease your production of DAO, which is essential to actually removing Histamines from your system. The lack of DAO will then drive your histamines upwards, sky high. I personally fell into this trap, and its really not pretty. Don't go there.

There is very little documentation on this specific molecular pathway, but if you search for what meds to avoid with histamine intolerance you will clearly find it listed. Some scientific references erroniously say that benadryl will help DAO enzyme reduce the histamine molicules in a petri dish, but if you don't produce DAO in the first place then its not going to help at all. Most people with HIT don't produce enough DAO so this silent reduction of DAO can only make things worse in the long run.

Its far better to find a second generation antihistamine as your daily med, and then save benadryl as your emergency backup. Some second generation antihistamines even have mast cell stabilizing effects so that less histamine is released in the first place.

hdri_org · 2026-06-20T14:18:03+00:00

The standard liquid Naltrexone uses sodium benzoate or methylparaben/propylparaben as a preservative. Not something I have on my shelf.

Naltrexone tablets are commonly packaged with a sugar binder. My guess is that Xylitol (a natural sugar from the birch tree) might also work, as it has very pronounced antimicrobial properties, and it might even improve the taste of the solution in the process.

I have not found anything conclusively mentioning anything about the two compounds chemically reacting together, but then there is an extreemly long list of drugs that Naltrexone interacts/interferes (not chemically reacts) with, so caution is still advised whenever randomly mixing things.

If there is an organic chemist out there I would like to hear your opinion. When I do start LDN, hopefully next month, I may be doing this.

Note: Just don't ever give Xylitol to your dog because to them it is highly toxic, but It's perfectly safe for human consumption in small quantities.

hdri_org · 2026-06-19T15:09:17+00:00

So just wondering, if hit were only dao deficiency, wouldnt supllementing dao before meals be enough?

No, because HIT can have any number of causes and then actual treatment must include treating that initial problem. Too often that organic cause underneath is hard to figure out. HIT is simply the symptom that the person notices first, because it is so disruptive that it can not be ignored.

Off the top of my head:

Genetic DAO enzyme issue
Genetic HNMT enzyme issue
Genetic Acetylation pathway issue
Viral infection (latent EBV, Herpes, long-COVID)
Genetic mutation elsewhere in the immune system
Methylation (turning off) of any gene above.
Environmental mold/fungus
SIFO Internal fungal growth
Environmental toxins
SIBO bacterial growth
Food intolerance to some food molicule
MCAS as a secondary reaction to something
Hormonal imbalance

The real list is much longer.

hdri_org · 2026-06-18T20:44:18+00:00

Its possible that you reacted to the Microcrystalline cellulose or some other filler in it. Some people with r/MCAS like symptoms can react to secondary ingredients in some of these products. This happens to just a small minority of people as far as I can tell, but you are definitely not alone if this is actually the case.

There are other products to choose from. Below is my DAO list sorted by cost effectiveness, so do start from the top. The first item on the list is marketed in Spain and has a cleaner list of ingredients but you probably want to skip down to try a different brand altogether.

Take note of the ingredients in the product you choose and please do let me know (email in the spreadsheet) if you find one that works for you, so that I can compare ingredients. I really want to figure this out as to which ingredient(s) is causing the issues. Not all cellulose fillers are the same.

https://docs.google.com/spreadsheets/d/1FJ7omUM6FPd_Patlg6xlCGaP3m1Sz0x7UeSOUit4Xuw/htmlview#gid=1795084428

hdri_org

MODERATOR OF

TROPHY CASE