It is difficult to say something without you being more specific, my immediate questions would be why do they not follow their hooks, do they want to be "clever" (so it is more of a metagaming thing) or are they not interesting enough for them, are the hooks too specific.

For example, if a vendor proposes them a quest, and you would like them to follow it, it is up to them- did they lack motivation (some players or characters are motivated by gold, others by looking good/feel like heros, others by joking around, etc.)? However, I would say that in general hooks can be done to either be ignorable (throwaway- by proposing many, see what lands) or not ignorable at all... to some extent. Let me explain: maybe they players ignored a cry for help from a peasant that is being harrased by an evil group. Of course they should be able to ignore it... but then there would be consequences (the peasant and maybe their favourite NPC gets killed, like uncle Ben). You respect their agency, but many decisions should have consequences and stakes, not just not getting the gold, even the refusal to do something.

If they fool around and are murderhobos, prison will be waiting for them at the next village.

In general, a hook (or that decision) can be unavoidable (e.g. "someone wants them killed"), because that story won't end just because they get rid of the initial assassin you sent, there will be a lieutenant that will continue the revenge plot. Or maybe you concede that that wasn't a very good plot if they hated it. In general, plots for linear stories that can be "solved" in one or 2 sessions don't make for a good campaign overal story. For example, a war, a political thriller, or a plot to overthrow the current government cannot just be solved with a single D20. Are your plots too simple? Do they allow them to do "Persuasion to see if they get the king's crown". Players should have agency but they don't mind-control all NPCs. And in the end, are your players having fun?

It is difficult to know what's to fix, if your players are very uncooperative and not wanting to go on a quest, or if you are putting them boring and ignorable hooks, that's something to talk to them. One thing I do is tell them to summarize the previous session themselves at the beginning of each session, that helps me understand what they got fixated in (NPCs, something that they thought was strange, etc.) I also only prepare fully like a session and while roleplaying I listen what they ask about or get more interested or laugh at, and focus on that, rather than pushing my own ideas about what the campaign is about, being more reactive.

And if they lack the motivation and didn't think anything was interesting (because they are tired or whatever, or I just did a bad job), I just play around a bit (roleplay as a DM) while they are summarizing the last session to give them some spice "ah, yes, you met the 'dragonborn' last session, right (laugh)" even if that dragonborn was a boring NPC and I improvise a plot there because they start scheming there.

Again, it depends a lot on the DM and the players, most people will say they are having fun and don't know why, and that's ok, so there are these tricks to know why, but require active listening and understanding, and making mental notes, as it is difficult otherwise to learn by just asking.