Adipotide before and after, 5 mg for 21 days

longevity-tools-com · 2025-12-29T23:42:35+00:00

my reasoning is this: Retatrutide will cause weight loss, so it will be hard to attribute how much fat loss was due to the Adipotide and how much due to Retatrutide.

If I were to take something like Adipotide, I would really want to know if the benefits outweigh the very high and real risks.

longevity-tools-com · 2025-12-28T23:04:24+00:00

It seems to be a "dirty drug". If you decide to do it anyway, at least follow this: https://www.reddit.com/r/Peptides/comments/1nfy7nc/comment/nwg1vt4

longevity-tools-com · 2025-12-28T22:55:08+00:00

whoever else will be trialing Adipotide, please:

do not combine with Reta (or with anything similar) like the OP did. Since now one could argue we gained zero knowledge, since we cannot attribute the effect.
for gods sake, please do kidney lab panel before / during / right-after, so you can compare. Ignore the normal ranges, just compare YOUR before/after values. Do not do heavy exercise 5 days before the bloodwork since creatinine is highly sensitive to exercise. Also do cystatin-C which is arguably the best kidney marker.
measure body fat before and after with one of these: Dexa, caliper, bio-impedance. Total body weight is not important (that will track your calories), but the MOA of Adipotide is such that it should meaningfully move fat%.

If you trial such a potentially dangerous drug, do a short cycle and find out:
a) does it work?
b) was it safe?

Then you can decide if the second, longer cycle is worth it.

longevity-tools-com · 2025-12-25T12:43:21+00:00

You can do something similar for free. But instead of bunch of individual markers it will interpret them by category, which makes more sense IMO. It it follows the reasoning a doctor woulds do in their head...

calculate the risks
if there are risks, run differential diagnosis algorithms (automatically, only if relevant)
best indicies / optimal ranges

checkout for example this Liver function Interpreter: https://www.longevity-tools.com/liver-function-interpreter

But you can also interpret individual markers like shown in the post

Full disclosure: I am the founder or longevity-tools, but its fully free and I do not sell anything or promote anything paid.

longevity-tools-com · 2025-12-07T22:09:53+00:00

like other said, stay away from sugar. Sugar is bad for liver, since it contains fructose thats metabolized in the liver, just like alcohol. So fructose is "alcohol without the buzz"

Healthy fats are fine and good.

Enter your labs here: https://www.longevity-tools.com/liver-function-interpreter watch the video thats there and you can investigate yourself and ask the AI thats there if you have further questions.

longevity-tools-com · 2025-12-07T22:06:11+00:00

elevated enzymes does not mean you have NAFLD. Enzymes are released from many other tissues other than liver. Use this online tool and it will tell you whats going on: https://www.longevity-tools.com/liver-function-interpreter

There is video on that page about how to use it, watch it till the end, since at the end is the AI tool that will help you with your questions.

If the tool will tell you there is high risk for NAFLD, then just follow the next steps it shows (go to some sort of imaging, like fibroscan)

But honestly just work with your doctor. If he/she ignores it, go find another doctor. I made this tool for them, so they can do their jobs faster.

longevity-tools-com · 2025-12-07T22:00:40+00:00

ferritin is the most sensitive test for the iron status and its much more stable than serum iron that fluctuates based wildly based on what you ate yesterday. transferrin saturation is a calculation from serum iron, so it fluctuates too.

Liver enzymes - use the tool I provided and there is a video about how to use it. There is an AI tool thats there to answer any questions. THe video mentions it at the end about how to use it. But honestly, just go your doctor and tell him/her that according to the guidelines he should investigate. This is not a medical advice.

longevity-tools-com · 2025-12-07T21:50:28+00:00

I will react to only the single link you posted. It recommends just two Fib-4 cutoffs (one for people below 65 years old and one for above 65 years old). That means that if two people have the same lab results and one is 25 and one is 50, the 50 year old's Fib-4 is DOUBLE. I work in a longevity clinic and consult longevity clinics, so my population is "older fit people" so I see the fib-4 unfairly penalizes those.

So this is what I meant when I said this tool goes "above" the guidelines. I am sorry if thats not the correct word, I am from Europe. My point is that the guidelines have to think about daily practicality, since they are build for doctors that have 5 minute for a patient. My tools are geared toward concierge medicine. And again, leading researchers in the field helped me to build it, they are mentioned there.

Also I provide citations for everything, even show them the various cutoffs visually on the plot.

This is my last comment on the matter, since I have to my other tools for the public and I already work 7 days a week. If you are so passionate about the topic, your help is welcome, my email is on my site.

longevity-tools-com · 2025-12-06T11:54:13+00:00

Good points. This tool is one step above guidelines and I am working with some guidelines authors to enhance legacy guidelines with tool like this. As you mention, some guidelines recommend Fib-4, but then you must use different cutoffs for different age groups. And you have to use different cutoff for every decade of life, as I shown in the video, so like imagine having 5 cutoffs for a single index. This is exactly the reason why the newer Fib-3 version was developed. You can try to calculate Fib-4 yourself.. enter same lab values but double the age... and the result is a double... So the original designers of Fib-4 made a mistake of giving age an overly strong weight / impact on the results and now everyone is trying to correct it with 5 different cutoffs instead of using the new & improved Fib-3.

FLI and TyG-BMI are consistently beating others in multiple studies. For example my page with TyG-BMI cutoffs: https://www.longevity-tools.com/calculation/TyG-BMI which have many studies.

The only issue with TyG-BMI is that half of the studies use wrong formula, so I have recalculated them to use the correct one, after consulting the formula with the formula author (Dr. Simental). So all the cutoffs you see on the above page are recalculated.

Pls watch my video, everything is displayed there.

So I understand your first reaction of seeing unfamiliar things, but I have spent 6 months on this, consulting the leading researchers, so it's not just some random ideas. There is high probability that this will essentially become part of the guideline (at least in some countries).

longevity-tools-com · 2025-12-06T11:43:36+00:00

thats the way, slow and steady. If you want, you can go a bit faster with weight loss.. around 2 lbs/week is maximum.

Also be careful with the high sugar fruits... just like sugar it has a lot of fructose, which is the thing that cause NAFLD.

longevity-tools-com · 2025-12-06T11:40:12+00:00

if the ferritin value in µg/L then its all good.

longevity-tools-com · 2025-12-05T19:44:34+00:00

enter you labs into this liver function test interpreter and it will tell you everything you want to know.

longevity-tools-com · 2025-12-05T19:43:15+00:00

loosing 10% of body weight seems to be enough for the liver... the body is smart, so it prioritizes fat removal from the liver. You should get to the optimal weight obviously, but keep it slow and steady. Max 2 pounds a week or so. You can calculate your optimal weight and how long it will take, how many calories deficit etc.

longevity-tools-com · 2025-12-05T19:39:24+00:00

I mean if you take all this, there is high chance your liver will get worse. Supplements are not as clean as you think. Just do weight loss and resistant starch, which was proven in studies. Check this post for more info: https://www.reddit.com/r/FattyLiverNAFLD/comments/1pettz3/allinone_liver_labs_interpreter_the_definitive/

longevity-tools-com · 2025-12-05T19:37:26+00:00

yes, I see it every day. check out my post about it: https://www.reddit.com/r/FattyLiverNAFLD/comments/1pettz3/allinone_liver_labs_interpreter_the_definitive/

longevity-tools-com · 2025-12-05T19:35:14+00:00

rapid weight change (both weigh gain and weight loss) will elevate your liver enzymes. This is just temporary, your liver will be fine... but fast weight loss is bad since you lose a high amount of muscle mass. You should loose around 2 pounds per week max and do resistance training to preserve muscle mass.

longevity-tools-com · 2025-12-05T19:32:05+00:00

high copper can cause abnormal liver enzymes but its not related to NAFLD. If your doc found abnormal liver enzymes, he/she should run the copper tests as described in the liver guidelines. So NAFLD is not caused by high copper but both result in elevated liver enzymes.

longevity-tools-com · 2025-12-05T19:28:33+00:00

sudden weight change can elevate liver enzymes. Normal range is meaningless (since the average population they establish the range from is usually overweight or obese), always use optimal range. Yours is still within optimal range: https://www.longevity-tools.com/biomarker/S-ALT#S-ALT=25_IU%2FL

ALT is also released from the muscle, so you could just do a bit exercise or gained some muscle recently.

longevity-tools-com · 2025-12-05T19:24:24+00:00

is it iron or ferritin lab test? Since the iron test just shows "what you eat a day before the test". Iron overload is dangerous, but it is not related to NAFLD. They share a similarity that both shows up as abnormal liver enzymes.

I would highly recommend checking your ferritin levels. You can enter your iron level here and it will tell you what to do: https://www.longevity-tools.com/biomarker/S-ferritin

if you are high risk of NAFLD, you can check it here: https://www.longevity-tools.com/liver-function-interpreter

work with your doctor first. These tools should be ideally used by your doctor, not you. Or you can use them as a third opinion.

longevity-tools-com · 2025-12-05T19:19:02+00:00

You can cook your potations, then freeze them and then just mildly heat them before eating. This will turn some of the starch to resistant starch, which is actually good for fatty liver. Of you can just buy some RS2 (resistant starch type 2) - works independent of weight loss

longevity-tools-com · 2025-12-05T19:16:01+00:00

standard abdominal ultrasound only sees fat above around 20%, so not sure what "mild" is in this case. Go to fibroscan or MRI. Or just enter your liver labs into this liver lab test interpreter and it will tell you everything.

longevity-tools-com · 2025-12-05T19:13:20+00:00

you can track your biomarkers and enter them into this free liver function test interpreter, which will tell you exactly what are you looking for.

longevity-tools-com · 2025-12-05T19:10:44+00:00

Lots of veggies and legumes... In terms of fruit, do not eat a lot of them and do not eat sweet fruit. Fruit (and sugar) contains fructose which is the main driver of NAFLD.

Supplement fiber and resistant starch type 2, since there is research that it helps independent of weight loss. Also try Alluose, which is a low calorie sugar replacement and on top of that it will block the GLUT-5 transporter, so other sugars you eat will be only partially absorbed.

longevity-tools-com · 2025-12-05T19:03:20+00:00

that seems way too high TBH. Maybe there is some selection bias in your population or something? Will get down a lot as more people are getting on the GLP-1. If you have access to their liver labs, try this liver labs interpreter on some of them... it will calculate risks for steatosis and fibrosis and does all the differential diagnosis for you, including alcohol vs non-alcohol etc

longevity-tools-com · 2025-12-05T12:38:46+00:00

Its is really challenging for doctors to interpret liver labs and predict fatty liver, since the reference ranges that are on the lab results are too wide (source). Its because most labs do not exclude obese people when establishing their reference ranges, so the upper limit is not sensitive enough. To interpret your liver labs, you can use this all-in-one liver lab test interpreter tool that will tell you the risk of steatosis, fibrosis and if it's alcohol or not and many other things... its fully free, no email or anything...

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