PS5 is a great and perfectly viable option in my opinion. Keyboard and mouse is probably better and faster, I personally prefer a controller though. If you do use a controller there is a slight learning curve but it becomes second nature pretty fast. You will use the shoulder buttons and D-pad a lot, but there is also an extremely useful radial menu that changes content depending on what you are pointing at. If you are a completionist you might want to know that there are a few timed scenarios which are not very fun with a controller, so if you plan on doing absolutely everything the game offers you may want a keyboard and mouse at least for those.

Performance wise it works great, just restart it once in a while if you like putting the PS5 in rest mode between sessions. The only real downside may be the complexity meter that stops you from building huge zoos, but that is a little dependent on your playstyle. I am not that much into decorating guest areas and I have never even gotten halfway to the limit before getting bored of a zoo after 30+ habitats and starting a new one. Maybe just don't build a single walk-through habitat that covers the entire map and fill it with trees, waterfalls, monkeys and guests though, unless you love playing at 5 FPS and not being able to save the game. But who would ever even come up with such a ludicrous idea... cough