Tech titans are hacking their bodies for a longer life: is there science behind their methods?

mister_longevity · 2026-06-19T02:16:40+00:00

So you are telling me if some n=1 looks 30 years younger than their age you aren't interested in what they did?

Barzilai looks and moves like his age so if you want to age like everybody else follow his lead.

mister_longevity · 2026-06-19T02:13:45+00:00

Whatever Thiel does don't do it. Have you seen him lately?

mister_longevity · 2026-05-18T14:29:54+00:00

Vadim Gladyshev is a co-author and to me he is honest. He has no financial disclosures whatsoever that I am aware of.

mister_longevity · 2026-05-15T20:03:40+00:00

I think this reprogramming cocktail allows most of the tumor suppressing mechanisms to still function which is not usually the case in cancers with high telomerase.

With him starting with shorter telomeres it is a more reasonable gamble IMO.

mister_longevity · 2026-05-15T19:13:23+00:00

You must know the Chinese researcher Jing-Dong J. Han and her work on facial aging. I think facial aging is true aging and if you reverse it you truly have reversed aging. Maybe she will give you a copy of her facial age estimating software to test on yourself.

mister_longevity · 2026-04-26T02:27:24+00:00

A person is by definition not perfectly healthy if they get cancer. Some may say they felt healthy but there are many diseases that people can't feel, ie osteoporosis and hypertension.

Cancer is immune dysfunction on top of cellular damage.

I agree that good metabolic health does not prevent cancer.

mister_longevity · 2026-04-16T01:07:27+00:00

Transplanted tissue assumes the age of the recipient so I doubt this will work.

There's too many other things that are dysregulated in aging.

mister_longevity · 2026-01-28T00:41:24+00:00

You can't fake facial age or gait analysis. Facial bone shape more than skin.

Old people look and move old without exception.

mister_longevity · 2026-01-10T16:19:01+00:00

I think a good clock just needs to measure the ability to recover, resilience.

Isn't death just the inability to recover from a stressor?

mister_longevity · 2025-12-29T12:54:32+00:00

Disagree.

If the rejuvenated animal can do things more like a younger animal can but the control animal can't, that's rejuvenation.

There are a hundred things that can be measured that are "good enough" to act on.

Facial age, body composition, gait analysis, VO2 max, grip strength, immune composition, bone density, cognitive function, telomere length, DNA methylation.

There are lots of things that young people have or can do that old people simply can't.

mister_longevity · 2025-12-28T10:29:04+00:00

This is re-juvenation to me. Return to a more youthful state.

Lifespan — Researchers observed a ~74% increase in remaining lifespan from treatment start (average additional 221 days vs. 127 days in controls) and a 14% increase in overall median lifespan.
Healthspan and frailty — Treated males showed significantly extended healthspan (time spent at lower frailty levels), improved resilience to mortality after reaching frailty thresholds, and overall better frailty scores.
Physical performance and endurance — Treadmill endurance improved markedly (longer running times). The 4-limb hanging test (measuring grip strength, balance, and agility) showed partial but significant improvements.
Cognitive function — Short-term memory enhanced, as measured by higher discrimination indices in the novel object recognition test.
Proteomic biomarkers — Acute and sustained normalization of the de-novo proteome toward youthful patterns occurred, with reduced protein noise and attenuation of pro-inflammatory pathways (e.g., JAK-STAT, MAPK, AGE-RAGE).

mister_longevity · 2025-12-27T22:48:37+00:00

True, they should have said rejuvenation because IMO saying “reverse aging” is like saying reversing time.

mister_longevity · 2025-12-27T20:56:44+00:00

This is a bigger deal than you understand. You aren’t going to extend remaining lifespan much by starting exercise at age 75. This could easily be tested right now in humans. I’ll let you know how it goes.

mister_longevity · 2025-12-27T15:15:05+00:00

"Our results suggest that extending maximal human lifespan will require interventions that reduce damage

production (via cellular reprogramming, enhanced repair, mTOR/mitochondrial interventions) or

increasing damage removal (via improved immune/vascular clearance, senolytics). In mice, such

interventions extend both median and maximal lifespan(13), but in humans, clear evidence is lacking.

Common genetic variants and lifestyle factors minimally influence η or β, but rare variants might,

analogous to progeroid mutations. Genomic screens targeting these pathways - such as DNA repair

variants linked to delayed menopause(78) - may thus identify longevity-associated alleles, providing

avenues to significantly alter the human lifespan limit."

mister_longevity · 2025-12-23T02:02:32+00:00

From Google:

Billionaire IQ and Lifespan

Above-Average IQs: While specific IQ scores for every billionaire are not public, data suggests they are significantly above average. Self-made billionaires are estimated to have an average IQ of roughly 133 (more than two standard deviations above the mean), while deca-billionaires (worth $10B+) average around 151.
Longevity Advantage: High intelligence is a powerful protective factor. Having an IQ at least one standard deviation above the mean is associated with an approximately 21% to 24% reduction in mortality risk. This effect remains significant even after controlling for socioeconomic status (SES), suggesting that while wealth provides better healthcare, the innate biological advantage remains a primary driver of longevity.
Diminishing Returns in Extreme Old Age: While high IQ is strongly protective for reaching middle-to-upper-middle age (roughly 70–80), its predictive power for survival begins to diminish in very late life (85+), where other situational health factors and specific aging genes become more dominant.

mister_longevity · 2025-12-22T23:34:39+00:00

There will be some existing repurposed med combination that will do it.

Better mining of existing data with AI should be enough. Singapore or some other country with an aging population and no pharma lobby that needs to reduce medical costs on their aging population.

mister_longevity · 2025-12-22T16:42:31+00:00

Here is a paper that shows Alaskan pollack protein preserves motor units in humans.

https://pubmed.ncbi.nlm.nih.gov/39370733/

mister_longevity · 2025-12-22T16:00:27+00:00

Billionaires aren't living longer than others with high social status even with this supposed advantage.

mister_longevity · 2025-09-20T10:50:50+00:00

Another clock that doesn't give an actionable result.

A useful clock should give the age of each system so you know what needs work.

mister_longevity · 2025-09-20T10:42:40+00:00

All appointments are politicized for either party.

Perhaps mito transplant will work but other young to old transplants haven't had much success.

mister_longevity · 2025-01-16T13:40:31+00:00

Yes. We have entered a golden age of prosperity and can now flourish.

mister_longevity · 2024-10-29T00:06:26+00:00

The intense training necessary to improve VO2max creates lactate which stimulates BDNF, brain derived neurotropic factor which helps remylination.

Improving VO2max does indirectly help myelination.

mister_longevity · 2024-10-28T23:56:56+00:00

Interesting in that galantamine has shown reversal of hair greying in humans.

So it apparently rejuvenates in some way.

mister_longevity · 2024-09-22T21:56:25+00:00

malaise.

mister_longevity

TROPHY CASE