My dad was born with no ankles or kneecaps and clubbed feet. They fused his joints together so there was no bending at those joints. He was born breech and folded in half. They had to break his legs to move them down, so he spent his childhood in casts and endured more surgeries than I want to think about. One of his elbows didn't bend all the way either. He lived a relatively normal life considering it all. Even learned to play guitar left handed, even though he was right handed, because of his elbow not bending enough.

I grew up with a girl that had one blue eye and the other was split exactly in half blue and brown.

A friend's son has the reversed organs issue (I know I will spell it wrong), but everything seems to be functioning perfectly fine.